J Cancer 2020; 11(22):6716-6726. doi:10.7150/jca.46293


MicroRNA-144: A novel biological marker and potential therapeutic target in human solid cancers

Meng Zhou1, Yuncui Wu1, Hongwu Li2✉, Xiaojun Zha1✉

1. Department of Biochemistry & Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei 230032, China.
2. Department of Otorhinolaryngology, Head & Neck Surgery, The Fourth Affiliated Hospital of Anhui Medical University, Hefei 230000, China.

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Zhou M, Wu Y, Li H, Zha X. MicroRNA-144: A novel biological marker and potential therapeutic target in human solid cancers. J Cancer 2020; 11(22):6716-6726. doi:10.7150/jca.46293. Available from http://www.jcancer.org/v11p6716.htm

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MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. It has been reported that microRNA-144 (miR-144) is highly conserved and can combine complementarily with the 3'-UTRs of target gene mRNAs to inhibit mRNA translation or promote targeted mRNA degradation. MiR-144 is abnormally expressed and has been identified as a tumor suppressor in many types of solid tumors. Increasing evidence supports a crucial role for miR-144 in modulating physiopathologic processes, such as proliferation, apoptosis, invasion, migration and angiogenesis in different tumor cells. Apart from these functions, miR-144 can also affect drug sensitivity, cancer treatment and patient prognosis. In this review, we summarize the biological functions of miR-144, its direct targets and the important signal pathways through which it acts in relation to various tumors. We also discuss the role of miR-144 in tumor biology and its clinical significance in detail and offer novel insights into molecular targeting therapy for human cancers.

Keywords: miRNA, miR-144, tumor development, cancer diagnosis, cancer prognosis, cancer treatment