Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

J Cancer 2020; 11(22):6704-6715. doi:10.7150/jca.45176 This issue Cite

Research Paper

Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells

Tuan Wang, Xia Wu, Mus'ab Al rudaisat, Yinjing Song, Hao Cheng✉

Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 3 Qingchun Road, Zhejiang, 310016, P.R. China.

✉ Corresponding author: Hao Cheng, M.D. Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 3 Qingchun Road, Zhejiang, 310016, PR. China. Tel.: +86 571 86006975; Fax: +86 571 8604481 More

Citation:
Wang T, Wu X, Al rudaisat M, Song Y, Cheng H. Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells. J Cancer 2020; 11(22):6704-6715. doi:10.7150/jca.45176. https://www.jcancer.org/v11p6704.htm
Other styles

File import instruction

Abstract

Our study explored the tumor-suppressive effect of curcumin on cervical cancer cells. Cervical cancer is one of the most common cancers among women worldwide. Acquired resistance to chemotherapeutics and toxicity of such drugs has undermined the effectiveness of cervical cancer treatments. Therefore, the identification of novel chemotherapeutics is key to improving the survival of patients with cervical cancer. Curcumin has been shown to have various bioactivities, including antioxidant and antitumor effects; however, its effect on cervical cancer remains elusive. Here, we used the SiHa human cervical cancer cell line to test various concentrations of curcumin on the proliferation and apoptosis of cervical cancer cells. The involvement of autophagy and reactive oxygen species (ROS) in these effects were also tested by using specific autophagy inhibitors and ROS scavengers. Our results showed that curcumin induced ROS accumulation, apoptosis, autophagy, cell cycle arrest, and cellular senescence accompanied by upregulation of p53 and p21 proteins in SiHa cells.

Keywords: curcumin, autophagy, ROS, cell senescence

Citation styles

APA
Wang, T., Wu, X., Al rudaisat, M., Song, Y., Cheng, H. (2020). Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells. Journal of Cancer, 11(22), 6704-6715. https://doi.org/10.7150/jca.45176.

ACS
Wang, T.; Wu, X.; Al rudaisat, M.; Song, Y.; Cheng, H. Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells. J. Cancer 2020, 11 (22), 6704-6715. DOI: 10.7150/jca.45176.

NLM
Wang T, Wu X, Al rudaisat M, Song Y, Cheng H. Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells. J Cancer 2020; 11(22):6704-6715. doi:10.7150/jca.45176. https://www.jcancer.org/v11p6704.htm

CSE
Wang T, Wu X, Al rudaisat M, Song Y, Cheng H. 2020. Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells. J Cancer. 11(22):6704-6715.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use