J Cancer 2020; 11(18):5257-5263. doi:10.7150/jca.42673

Research Paper

The Clinical Application of Core-Needle Biopsy after Radiofrequency Ablation for Low-risk Papillary Thyroid Microcarcinoma: A Large Cohort of 202 Patients Study

Lin Yan1,2,3, Yukun Luo2,1✉, Ying Zhang2,4, Yaqiong Zhu2,4, Jing Xiao2,4, Yu Lan2,4, Xiaoqi Tian2,4, Qing Song2, Fang Xie2

1. Medical School of Chinese PLA, No.28 Fuxing Road, Haidian District, Beijing, China.
2. Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, No.28 Fuxing Road, Haidian District, Beijing, China.
3. Health Management Center, The Second Hospital of Dalian Medical University, No.467 Zhongshan Road, Shahekou District, Dalian, China.
4. School of Medicine, Nankai University, No.94 Weijing Road, Nankai District, Tianjing, China.

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Citation:
Yan L, Luo Y, Zhang Y, Zhu Y, Xiao J, Lan Y, Tian X, Song Q, Xie F. The Clinical Application of Core-Needle Biopsy after Radiofrequency Ablation for Low-risk Papillary Thyroid Microcarcinoma: A Large Cohort of 202 Patients Study. J Cancer 2020; 11(18):5257-5263. doi:10.7150/jca.42673. Available from https://www.jcancer.org/v11p5257.htm

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Abstract

Purpose: To evaluate the clinical application of core-needle biopsy (CNB) for low-risk papillary thyroid microcarcinoma (PTMC) after radiofrequency ablation (RFA)

Methods: A total of 202 patients with 211 low-risk PTMCs were included in this study. RFA procedure was used the hydrodissection technique and moving-shot technique. Patients were followed at 1, 3, 6, 12 months and every 6 months thereafter. The volume of ablation area and the volume reduction ratio (VRR) were calculated. At 3 or 6 months after RFA, CNB was performed to the central zone, the peripheral zone and surrounding thyroid parenchyma for post-ablation evaluation.

Results: The mean volume of tumors was 102.34±93.84 mm3 (range 4.19-424.10 mm3), which decreased significantly to 1.37±7.74 mm3 (range 0-73.30 mm3) at a mean follow-up time of 24.42±9.15 months (range 3-42 months) with a mean VRR of 99.14±4.18% (range 71.88-100%). A total of 3 ablation areas had positive CNB in the peripheral zone and underwent additional RFA. No recurrent or suspicious metastatic lymph nodes were detected

Conclusion: CNB is a feasible and effective evaluation for low-risk PTMC after RFA, which can detect residual cancer cells early.

Keywords: radiofrequency ablation, papillary thyroid microcarcinoma, core-needle biopsy, ultrasound.