Multiple Mechanisms Involving in Radioresistance of Nasopharyngeal Carcinoma

Zhan, Yuting; Fan, Songqing

doi:10.7150/jca.39354

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2020; 11(14):4193-4204. doi:10.7150/jca.39354 This issue Cite

Review

Multiple Mechanisms Involving in Radioresistance of Nasopharyngeal Carcinoma

Yuting Zhan, Songqing Fan^✉

Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Citation:

Zhan Y, Fan S. Multiple Mechanisms Involving in Radioresistance of Nasopharyngeal Carcinoma. J Cancer 2020; 11(14):4193-4204. doi:10.7150/jca.39354. https://www.jcancer.org/v11p4193.htm

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Abstract

Nasopharyngeal carcinoma (NPC) is the malignant tumor with ethnic and geographical distribution preference. Although intensity-modulated radiotherapy (IMRT)-based radiotherapy combined with chemotherapy and targeted therapy has dramatically improved the overall survival of NPC patients, there are still some patients suffering from recurrent tumors and the prognosis is poor. Multiple mechanisms may be responsible for radioresistance of NPC, such as cancer stem cells (CSCs) existence, gene mutation or aberrant expression of genes, epigenetic modification of genes, abnormal activation of certain signaling pathways, alteration of tumor microenvironment, stress granules (SGs) formation, etc. We conduct a comprehensive review of the published literatures focusing on the causes of radioresistance, retrospect the regulation mechanisms following radiation, and discuss future directions of overcoming the resistance to radiation.

Keywords: nasopharyngeal carcinoma, radioresistance, mechanism

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APA

Zhan, Y., Fan, S. (2020). Multiple Mechanisms Involving in Radioresistance of Nasopharyngeal Carcinoma. Journal of Cancer, 11(14), 4193-4204. https://doi.org/10.7150/jca.39354.

ACS

Zhan, Y.; Fan, S. Multiple Mechanisms Involving in Radioresistance of Nasopharyngeal Carcinoma. J. Cancer 2020, 11 (14), 4193-4204. DOI: 10.7150/jca.39354.

NLM

Zhan Y, Fan S. Multiple Mechanisms Involving in Radioresistance of Nasopharyngeal Carcinoma. J Cancer 2020; 11(14):4193-4204. doi:10.7150/jca.39354. https://www.jcancer.org/v11p4193.htm

CSE

Zhan Y, Fan S. 2020. Multiple Mechanisms Involving in Radioresistance of Nasopharyngeal Carcinoma. J Cancer. 11(14):4193-4204.

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