J Cancer 2020; 11(12):3580-3587. doi:10.7150/jca.36355

Research Paper

The Role of Formyl Peptide Receptor 1 Gene Polymorphisms in Human Colorectal Cancer

Shu-Qin Li1,2*, Yang Yu1*, Yan Zhang1, Yan-Ping Sun3, Xin-xing Li3✉, Ning Su3✉

1. School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
2. School of Pharmacy, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin Road (No.2), Shanghai, 200025, China.
3. Department of General Surgery, Shanghai Chang Zheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China.
*These authors contributed equally to this work.

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Citation:
Li SQ, Yu Y, Zhang Y, Sun YP, Li Xx, Su N. The Role of Formyl Peptide Receptor 1 Gene Polymorphisms in Human Colorectal Cancer. J Cancer 2020; 11(12):3580-3587. doi:10.7150/jca.36355. Available from http://www.jcancer.org/v11p3580.htm

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Abstract

Formyl peptide receptor 1 (FPR1) belongs to G protein-coupled receptors expressed mainly in phagocytic leukocytes. The gene encoding FPR1 is highly polymorphic and related to inflammation. In this study, we investigated the single nucleotide polymorphisms (SNPs) of Fpr1 in human colorectal cancer (CRC), and analyzed the association of Fpr1 SNPs with clinicopathological parameters and some specific diagnostic markers of CRC. Although the allele and genotype frequencies of Fpr1 SNPs in CRC tissues were not significantly different from that in whole blood cells derived from healthy Chinese subjects. Significant associations were observed between genotypes of c.289C>A and distant metastasis (P=0.001), and between genotypes of c.306T>C and tumor size (P=0.016). Genotypes of c.546C>A was closer to tumor size and lymphatic invasion (P=0.012 and P=0.043, respectively). Meanwhile, genotypes of c.1037C>A was related with tumor location and differentiation (P=0.000 and P=0.005, respectively). Besides, genotypes of c.576T>C>G was related with pathological type (P=0.000). Furthermore, several Fpr1 SNP positions including c.289 (C>A) and c.576 (G>C>T) were related to the expression of P53 (P=0.004 and P=0.008, respectively), and similar results were observed between other Fpr1 SNP positions and CEA, HER2 and Ki-67 (P<0.05). Our data demonstrate that Fpr1 SNPs may play the important role in the progression and metastasis of CRC.

Keywords: Colorectal cancer, Formyl peptide receptor 1, Single nucleotide polymorphisms, Metastasis