J Cancer
2020; 11(12):3519-3535.
doi:10.7150/jca.41841 This issueCite
Review
Lysophosphatidic Acid Receptors: Biochemical and Clinical Implications in Different Diseases
Hongjiao Xiang, Yifei Lu, Mingmei Shao, Tao Wu✉
Center of Chinese Medical Therapy and Systems Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
✉ Corresponding author: Tao Wu, PhD, Assistant Professor, Center of Chinese Medical Therapy and Systems Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China. E-mail: tw827edu.cn or wutao001827com. Telephone: +86-21-51322748; Fax: +86-21-51322748.More
Citation:
Xiang H, Lu Y, Shao M, Wu T. Lysophosphatidic Acid Receptors: Biochemical and Clinical Implications in Different Diseases. J Cancer 2020; 11(12):3519-3535. doi:10.7150/jca.41841. https://www.jcancer.org/v11p3519.htm
Lysophosphatidic acid (LPA, 1-acyl-2-hemolytic-sn-glycerol-3-phosphate) extracted from membrane phospholipid is a kind of simple bioactive glycophospholipid, which has many biological functions such as stimulating cell multiplication, cytoskeleton recombination, cell survival, drug-fast, synthesis of DNA and ion transport. Current studies have shown that six G-coupled protein receptors (LPAR1-6) can be activated by LPA. They stimulate a variety of signal transduction pathways through heterotrimeric G-proteins (such as Gα12/13, Gαq/11, Gαi/o and GαS). LPA and its receptors play vital roles in cancers, nervous system diseases, cardiovascular diseases, liver diseases, metabolic diseases, etc. In this article, we discussed the structure of LPA receptors and elucidated their functions in various diseases, in order to better understand them and point out new therapeutic schemes for them.
Keywords: lysophosphatidic acid, LPAR, structure, physiology and pathology, cancer
Citation styles
APA
Xiang, H., Lu, Y., Shao, M., Wu, T. (2020). Lysophosphatidic Acid Receptors: Biochemical and Clinical Implications in Different Diseases. Journal of Cancer, 11(12), 3519-3535. https://doi.org/10.7150/jca.41841.
ACS
Xiang, H.; Lu, Y.; Shao, M.; Wu, T. Lysophosphatidic Acid Receptors: Biochemical and Clinical Implications in Different Diseases. J. Cancer 2020, 11 (12), 3519-3535. DOI: 10.7150/jca.41841.
NLM
Xiang H, Lu Y, Shao M, Wu T. Lysophosphatidic Acid Receptors: Biochemical and Clinical Implications in Different Diseases. J Cancer 2020; 11(12):3519-3535. doi:10.7150/jca.41841. https://www.jcancer.org/v11p3519.htm
CSE
Xiang H, Lu Y, Shao M, Wu T. 2020. Lysophosphatidic Acid Receptors: Biochemical and Clinical Implications in Different Diseases. J Cancer. 11(12):3519-3535.
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