J Cancer 2020; 11(9):2540-2551. doi:10.7150/jca.37604

Review

Application of metabolomics in the diagnosis of breast cancer: a systematic review

Liqing Yang1, Ying Wang1, Haishan Cai1, Shuang Wang1, Yueping Shen2, Chaofu Ke2✉

1. Medical College of Soochow University, Suzhou 215123, P. R. China.
2. Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou 215123, P. R. China.

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Citation:
Yang L, Wang Y, Cai H, Wang S, Shen Y, Ke C. Application of metabolomics in the diagnosis of breast cancer: a systematic review. J Cancer 2020; 11(9):2540-2551. doi:10.7150/jca.37604. Available from http://www.jcancer.org/v11p2540.htm

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Abstract

Breast cancer (BC) remains the most frequent type of cancer in females worldwide. However, the pathogenesis of BC is still under the cloud, along with the huge challenge of early diagnosis, which is widely acknowledged as the key to a successful therapy. Metabolomics, a newborn innovative technique in recent years, has demonstrated great potential in cancer-related researches. The aim of this review is to look back on clinical and cellular metabolomic studies in the diagnosis of BC over the past decade, and provide a systematic summary of metabolic biomarkers and pathways related to BC diagnosis.

Keywords: Breast Cancer, Metabolomics, Diagnosis