ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2020; 11(5):1277-1287. doi:10.7150/jca.35444 This issue Cite
Research Paper
M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling
1. Department of Biliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
2. Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, Shanghai, China.
3. Department of Liver Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
4. CITIC Xiangya Reproductive and Genetic Specialist Hospital, Changsha, 410008, China.
5. Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Abstract
The roles of M2 macrophages on promoting tumor progression and chemotherapy resistance have been well studied in many cancers, such as pancreatic cancer, kidney cancer and so on, but its linkage to HCC cells still remains unclear. Here we found that M2 macrophages could alter miR-149-5p to increase MMP9 expression in HCC cells and mechanism dissection revealed that miR-149-5p might directly target the 3'UTR of MMP9-mRNA to suppress its translation. The in vivo orthotopic xenografts mouse model with oemiR-149-5p also validated in vitro data. Together, these findings suggest that M2 macrophages may through altering the miR-149-5p to promote HCC progression and targeting the M2 macrophages/miR149-5P/MMP9 signaling may help in the development of the novel therapies to better suppress the HCC progression.
Keywords: Liver cancer, MiRNA-149-5p, MMP9, Invasion, Migration
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