J Cancer 2020; 11(5):1250-1256. doi:10.7150/jca.37890

Review

Antitumor functions and mechanisms of nitidine chloride in human cancers

Yue Cui1, Linhui Wu1, Ruoxue Cao1, Hui Xu2, Jun Xia3✉, Z Peter Wang3,4✉, Jia Ma3✉

1. Research Center of Clinical Laboratory Science, School of Laboratory Medicine, Bengbu Medical College, Anhui, China, 233030, China.
2. Department of Laboratory Medicine, School of Laboratory Medicine, Bengbu Medical College, Anhui, 233030, China.
3. Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical College, Anhui, 233030, China.
4. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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Citation:
Cui Y, Wu L, Cao R, Xu H, Xia J, Wang ZP, Ma J. Antitumor functions and mechanisms of nitidine chloride in human cancers. J Cancer 2020; 11(5):1250-1256. doi:10.7150/jca.37890. Available from http://www.jcancer.org/v11p1250.htm

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Abstract

Nitidine chloride (NC), a quaternary ammonium alkaloid, exhibits multiple biological activities, including antimalarial, antifungal, and antiangiogenesis. Recently, NC has been characterized to perform antitumor activity in a variety of malignancies. NC has been identified to suppress cell proliferation, stimulate apoptosis, and induce cell cycle arrest, retard migration, invasion and metastasis. Moreover, NC is reported to sensitize cancer cells to chemotherapeutic drugs. In this review article, we describe the functions of NC in human cancers and discuss the molecular insight into NC-involved antitumor feature. This review article will stimulate the deeper investigation for using NC as a potent agent for the management of cancer patients.

Keywords: Nitidine chloride, Cancer, Therapy, Target, Antitumor