J Cancer 2020; 11(4):769-775. doi:10.7150/jca.38785

Review

The Effect of the Tumor Microenvironment and Tumor-Derived Metabolites on Dendritic Cell Function

Jun-Ho Lee1,2, So-Yeon Choi1, Nam-Chul Jung2, Jie-Young Song3, Han Geuk Seo4, Hyun Soo Lee2, Dae-Seog Lim1✉

1. Department of Biotechnology, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi-do 13488, Republic of Korea.
2. Pharos Vaccine Inc., 545 Dunchon-daero, Jungwon-gu, Seongnam, Gyeonggi-do 13215, Republic of Korea.
3. Department of Radiation Cancer Sciences, Korea Institute of Radiological and Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 01812, Republic of Korea.
4. Department of Food Science and Biotechnology of Animal Products, Sanghuh College of Life Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

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Citation:
Lee JH, Choi SY, Jung NC, Song JY, Seo HG, Lee HS, Lim DS. The Effect of the Tumor Microenvironment and Tumor-Derived Metabolites on Dendritic Cell Function. J Cancer 2020; 11(4):769-775. doi:10.7150/jca.38785. Available from http://www.jcancer.org/v11p0769.htm

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Abstract

Dendritic cells (DCs) have a critical effect on the outcome of adaptive immune responses against growing tumors. Recent studies on the metabolism on DCs provide new insights on the functioning of these critical controllers of innate and adaptive immunity. DCs within the tumor microenvironment (TME) often exist in an inactive state, which is thought to limit the adaptive immune response elicited by the growing tumor. Tumor-derived factors in the TME are known to suppress DC activation and result in functional alterations in DC phenotype. We are now beginning to appreciate that many of these factors can also induce changes in immune cell metabolism. In this review, we discuss the functional alternation of DC phenotype by tumor metabolites.

Keywords: dendritic cells, tumor microenvironment, exogenous factor, metabolite.