J Cancer 2019; 10(27):6848-6857. doi:10.7150/jca.36614

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A perspective profile of ADCY1 in cAMP signaling with drug-resistance in lung cancer

Ting Zou1,2,3*, Junyan Liu4*, Li She5,6, Juan Chen7, Tao Zhu2, Jiye Yin2, Xi Li2, Xiangping Li2, Honghao Zhou2, Zhaoqian Liu2,3✉

1. National Institution of Drug Clinical Trial, Xiangya Hospital, Central South University, Changsha, Hunan, P.R.China
2. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R.China
3. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R.China
4. Department of Orthopaedics, The First Affiliated Hospital of the University of South China, Hengyang, Hunan, P.R.China
5. Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University
6. Otolaryngology Major Disease Research Key Laboratory of Hunan Province
7. Changsha, Hunan, P.R.China. Department of pharmacy, Xiangya hospital, Central South University, Changsha, Hunan, P.R.China
*These authors contribute to this work equally

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Citation:
Zou T, Liu J, She L, Chen J, Zhu T, Yin J, Li X, Li X, Zhou H, Liu Z. A perspective profile of ADCY1 in cAMP signaling with drug-resistance in lung cancer. J Cancer 2019; 10(27):6848-6857. doi:10.7150/jca.36614. Available from http://www.jcancer.org/v10p6848.htm

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Abstract

Adenylate cyclase 1 (ADCY1 or AC1) is a member of ADCY superfamily and was primarily found to be expressed in the brain. ADCY1 is responsible for catalyzing ATP to cyclic AMP (cAMP). As a secondary messenger, cAMP can regulate plenty of cellular activities. cAMP can perform its regulation in cellular transport through the binding to cAMP dependent protein kinases (PKAs), cAMP-activated guanine exchange factors (EPACs) and cyclic nucleotide-gated channels functioning in transduction of sensory signals (CNGs). Lung cancer is one of the leading factors of cancer-related death worldwide. Platinum-based chemotherapy is the first-line treatment for advanced lung cancer patients. In addition, surgical treatment, radiation treatment, and molecular targeted therapy are also therapeutic options for lung cancer patients in clinical settings. However, drug resistance and toxicity are the major obstacles that affect chemotherapy outcome and prognosis of lung cancer patients. And the therapeutic efficiency and adverse effects are varying with each individual. In recent years, investigations based on genetic sequencing have revealed the emerging role of ADCY1 mutations in affecting drug efficiency in various cancers such as lung cancer, esophageal cancer and colorectal cancer. The potential function of ADCY1 in chemotherapy resistance is of great importance to be noticed and investigated.

Keywords: ADCY1, cAMP, Lung cancer, Drug resistance, Signaling pathway