J Cancer 2019; 10(26):6738-6746. doi:10.7150/jca.35770

Review

The emerging role of long non-coding RNAs in tumor-associated macrophages

Dafei Han, Yilong Fang, Yawei Guo, Wenming Hong, Jiajie Tu, Wei Wei

Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, China

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Citation:
Han D, Fang Y, Guo Y, Hong W, Tu J, Wei W. The emerging role of long non-coding RNAs in tumor-associated macrophages. J Cancer 2019; 10(26):6738-6746. doi:10.7150/jca.35770. Available from http://www.jcancer.org/v10p6738.htm

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Abstract

Tumor-associated macrophages (TAMs) are an important cellular component of the tumor microenvironment (TME) and play an essential role in tumor immunity. Recently, numerous studies have indicated that long non-coding RNAs (lncRNAs) can affect several functions of TAMs. In the present review, we summarize the versatile role of lncRNAs in the polarization, epigenetic modulation, and classic signaling pathways of TAMs, which represent a potential target for tumor diagnosis or treatment.

Keywords: lncRNAs, TAMs, polarization, epigenetics, NF-κB pathway