J Cancer 2019; 10(24):6105-6113. doi:10.7150/jca.32927


CircRNAs and its relationship with gastric cancer

Xinxin Fang1,2, Jing Wen1,2, Mingjun Sun2,3, Yuan Yuan1,3✉, Qian Xu1,3✉

1. Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang, China.
2. Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang City, Liaoning Province, China.
3. Key Laboratory of Gastrointestinal Cancer Etiology and Screening, Liaoning Province, Shenyang 110001, China

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Fang X, Wen J, Sun M, Yuan Y, Xu Q. CircRNAs and its relationship with gastric cancer. J Cancer 2019; 10(24):6105-6113. doi:10.7150/jca.32927. Available from http://www.jcancer.org/v10p6105.htm

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Circular RNAs (circRNAs), as a type of tissue specific RNA with more stable structure than linear RNAs, was poorly understood on its correlation with gastric cancer (GC). In this review, we outline the synthesis and characteristics of circRNAs and generalize their categories and functions. Through comprehensive analysis of the reported results, we find that circRNAs not only participate in the regulation of gastric cancer (GC) cell biological behaviors, such as proliferation, invasion, migration and epithelial mesenchymal transition (EMT), but also are related to the clinicopathological features of GC such as tumor differentiation, TNM stage and metastasis, etc. According to the present screening and verification results, circRNAs are suggested to be used as biomarkers for the early diagnosis and prognosis prediction of GC, and those circRNAs involved in the genesis and development of GC have the potential as novel targets for the individualized treatment of GC.

Keywords: circRNA, gastric cancer, cell biological behaviors, diagnosis, prognosis