Emerging roles of circRNA in formation and progression of cancer

Yin, Yuting; Long, Jiali; He, Qinglian; Li, Yuling; Liao, Yanqiu; He, Peishan; Zhu, Wei

doi:10.7150/jca.30828

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2019; 10(21):5015-5021. doi:10.7150/jca.30828 This issue Cite

Review

Emerging roles of circRNA in formation and progression of cancer

Yuting Yin^*, Jiali Long^*, Qinglian He, Yuling Li, Yanqiu Liao, Peishan He, Wei Zhu^✉

Department of Pathology, Guangdong Medical University, Dongguan 523808, Guangdong Province, China
^*Contributed equally

Citation:

Yin Y, Long J, He Q, Li Y, Liao Y, He P, Zhu W. Emerging roles of circRNA in formation and progression of cancer. J Cancer 2019; 10(21):5015-5021. doi:10.7150/jca.30828. https://www.jcancer.org/v10p5015.htm

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Abstract

Circular RNAs (circRNAs) are recently discovered as a special novel type of endogenous noncoding RNAs (ncRNAs), which form a covalently closed continuous loop and are highly represented in the eukaryotic transcriptome. Recent research revealed that circRNAs can function as microRNA (miRNA) sponges, regulators of splicing and transcription, as well as interact with RNA-binding proteins (RBPs). In this review, not only the function and mechanism, but also the experimental methods of circRNA are summarized. The summary of the current state of circRNA will help us in the discovery of novel biomarkers, the therapeutic targets and their potential significance in diagnosis and treatment of diseases. CircRNAs might play important roles in cancers especially in hepatocellular carcinoma, gastric carcinoma and colorectal cancer as well as serving as diagnostic or predictive biomarkers of some diseases and providing new treatments of diseases.

Keywords: circular RNA, microRNA, cancer, colorectal cancer

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APA

Yin, Y., Long, J., He, Q., Li, Y., Liao, Y., He, P., Zhu, W. (2019). Emerging roles of circRNA in formation and progression of cancer. Journal of Cancer, 10(21), 5015-5021. https://doi.org/10.7150/jca.30828.

ACS

Yin, Y.; Long, J.; He, Q.; Li, Y.; Liao, Y.; He, P.; Zhu, W. Emerging roles of circRNA in formation and progression of cancer. J. Cancer 2019, 10 (21), 5015-5021. DOI: 10.7150/jca.30828.

NLM

CSE

Yin Y, Long J, He Q, Li Y, Liao Y, He P, Zhu W. 2019. Emerging roles of circRNA in formation and progression of cancer. J Cancer. 10(21):5015-5021.

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