J Cancer 2019; 10(16):3593-3607. doi:10.7150/jca.30975

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Associations of mRNA expression of DNA repair genes and genetic polymorphisms with cancer risk: a bioinformatics analysis and meta-analysis

Huizhe Wu1#, Shanqiong Li1#, Xiaoyun Hu1, Wenyan Qin1, Yilin Wang1, Tong Sun, Zhikun Wu1, Xiufang Wang1, Senxu Lu1, Dongping Xu1, Yalun Li2, Shu Guan3, Haishan Zhao1, Weifan Yao1, Mingyan Liu1, Minjie Wei1✉

1. Department of Pharmacology, School of Pharmacy, Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation, China Medical University, Shenyang, 110122, P. R. China
2. Department of Anorectal Surgery, First Hospital of China Medical University, Shenyang, 110001, P. R. China
3. Department of Breast Surgery, First Hospital of China Medical University, Shenyang, 110001, P. R. China
#Contribute equally to this work.

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Citation:
Wu H, Li S, Hu X, Qin W, Wang Y, Sun T, Wu Z, Wang X, Lu S, Xu D, Li Y, Guan S, Zhao H, Yao W, Liu M, Wei M. Associations of mRNA expression of DNA repair genes and genetic polymorphisms with cancer risk: a bioinformatics analysis and meta-analysis. J Cancer 2019; 10(16):3593-3607. doi:10.7150/jca.30975. Available from http://www.jcancer.org/v10p3593.htm

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Abstract

A systematical bioinformatics and meta-analysis were carried out to establish our understanding of possible relationships between DNA repair genes and the development of cancer. The bioinformatics analysis confirmed that lower XPA and XPC levels and higher XPD, XPF, and WRN levels were observed in 19 types of cancer, and subsequently results indicated that elevated XPA and XPC had a better impact on overall survival, however, higher XPD, XPF, and WRN showed worse influence on cancer prognosis. The meta-analysis included 58 eligible studies demonstrated that harboring XPA rs10817938, XPD rs238406 increased overall cancer risk, however, XPA rs2808668 SNP in overall cancer analysis and XPF rs3136038 in the digestive system remarkably reduced the cancer risk. Moreover, no correlation was investigated for XPC rs1870134, WRN rs1346044 and rs1801195. These suggest that the DNA repair gene was associated with carcinogenesis, and contribute to the prognosis, and the critical SNPs further involved in affecting cancer risk.

Keywords: DNA repair genes, bioinformatics, cancer, prognosis, meta-analysis