EMP2 acts as a suppressor of melanoma and is negatively regulated by mTOR-mediated autophagy

Wang, Manyi; Li, Sijia; Zhang, Peng; Wang, Yujia; Wang, Chunting; Bai, Ding; Jiang, Xian

doi:10.7150/jca.30342

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International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2019; 10(16):3582-3592. doi:10.7150/jca.30342 This issue Cite

Research Paper

EMP2 acts as a suppressor of melanoma and is negatively regulated by mTOR-mediated autophagy

Manyi Wang^1,*, Sijia Li^1,*, Peng Zhang^2,✉, Yujia Wang³, Chunting Wang³, Ding Bai^1✉, Xian Jiang^3✉

1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Disease, Department of Orthodontics and Paediatrics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China
2. Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu 610041, PR China
3. Department of Dermatology and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, PR China
^* These authors contributed equally.

Citation:

Wang M, Li S, Zhang P, Wang Y, Wang C, Bai D, Jiang X. EMP2 acts as a suppressor of melanoma and is negatively regulated by mTOR-mediated autophagy. J Cancer 2019; 10(16):3582-3592. doi:10.7150/jca.30342. https://www.jcancer.org/v10p3582.htm

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Abstract

Cutaneous melanoma is one of the most common malignant skin tumors and advanced melanoma is usually associated with a poor prognosis. In the current study, we demonstrated the tumor suppressing role of epithelial membrane protein-2 (EMP2) by inducing apoptosis in a A375 human melanoma cell line. Mechanistically, the low expression of EMP2 in melanoma is partially due to autophagic protein degradation mediated by the mTOR pathway. These results suggest there is regulation of autophagy as well as EMP2 levels might be an interesting novel targeted therapeutic strategy for melanoma. Although the further investigation is needed to deeply understand the regulatory mechanisms of EMP2 in melanoma progression and metastasis, our results clarify the functions and mechanisms of autophagy in melanoma, and shed new light on novel targeted therapeutics for melanoma.

Keywords: EMP2, mTOR, Apoptosis, Autophagy, Melanoma.

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APA

Wang, M., Li, S., Zhang, P., Wang, Y., Wang, C., Bai, D., Jiang, X. (2019). EMP2 acts as a suppressor of melanoma and is negatively regulated by mTOR-mediated autophagy. Journal of Cancer, 10(16), 3582-3592. https://doi.org/10.7150/jca.30342.

ACS

Wang, M.; Li, S.; Zhang, P.; Wang, Y.; Wang, C.; Bai, D.; Jiang, X. EMP2 acts as a suppressor of melanoma and is negatively regulated by mTOR-mediated autophagy. J. Cancer 2019, 10 (16), 3582-3592. DOI: 10.7150/jca.30342.

NLM

CSE

Wang M, Li S, Zhang P, Wang Y, Wang C, Bai D, Jiang X. 2019. EMP2 acts as a suppressor of melanoma and is negatively regulated by mTOR-mediated autophagy. J Cancer. 10(16):3582-3592.

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