J Cancer 2019; 10(13):3006-3011. doi:10.7150/jca.30903

Research Paper

Serum Prealbumin is Negatively Associated with Survival in Hepatocellular Carcinoma Patients after Hepatic Resection

Ying-Yang Liao1#, Chun-Lan Teng2#, Ning-Fu Peng2,3#, Rong-Rong Jia2,3, Jing Cui2, Kang Chen2, Liang Ma2,3, Bang-De Xiang2,3✉, Jian-Hong Zhong2,3✉, Le-Qun Li2,3

1. Department of Nutrition, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China
2. Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China
3. Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center, Nanning, China
#These authors contributed equally to this work.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Liao YY, Teng CL, Peng NF, Jia RR, Cui J, Chen K, Ma L, Xiang BD, Zhong JH, Li LQ. Serum Prealbumin is Negatively Associated with Survival in Hepatocellular Carcinoma Patients after Hepatic Resection. J Cancer 2019; 10(13):3006-3011. doi:10.7150/jca.30903. Available from http://www.jcancer.org/v10p3006.htm

File import instruction

Abstract

Objective: Low serum prealbumin levels are associated with poor prognoses in some type of cancers. However, the role of prealbumin in patients with hepatocellular carcinoma (HCC) is unknown. The present study aimed to investigate the role of serum prealbumin levels in long-term survival for HCC patients after hepatic resection.

Methods: HCC patients who underwent hepatic resection from June 2007 to December 2015 were retrospectively analyzed in a tertiary liver center. Patients were classified as having normal or reduced serum prealbumin based on a cut-off value of 200 mg/L. Overall survival and recurrence rate were analyzed between groups. Propensity score analysis was used to reduce bias due to other patient differences at baseline.

Results: A total of 1349 HCC patients who underwent hepatic resection were enrolled on this study, including 1168 (86.6%) male and 181 (13.4%) female. Patients with normal serum prealbumin had significantly higher overall survival than those with reduced serum prealbumin (P < 0.001). Similar findings were observed after propensity analysis and subgroup analysis based on liver cirrhosis. Moreover, patients with normal serum prealbumin had a significantly lower recurrence rate than those with reduced serum prealbumin (P < 0.001).

Conclusions: Low preoperative level of serum prealbumin is associated with poor long-term survival in patients with HCC after hepatic resection. Low serum prealbumin may be a marker to identify patients at high risk of poor prognosis after hepatic resection.

Keywords: humans, clinical study, prognosis