Prevalence and Characteristics of hrHPV Infection among 414,540 Women: A Multicenter Study in Central and Eastern China

Wang, Yi; Meng, Yifan; Li, Wending; Zhang, Xiaofei; Deng, Zaixing; Hu, Mengjun; Shen, Pingrong; Xu, Shengfeng; Fu, Chenglin; Jiang, Wen; Wu, Bing; Li, Kezhen; Chen, Gang; Wei, Juncheng; Xi, Ling; Hu, Junbo; Xie, Xing; Ma, Ding; Cheng, Xiaodong; Wu, Peng

doi:10.7150/jca.30157

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International Journal of Medical Sciences

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J Cancer 2019; 10(8):1902-1908. doi:10.7150/jca.30157 This issue Cite

Research Paper

Prevalence and Characteristics of hrHPV Infection among 414,540 Women: A Multicenter Study in Central and Eastern China

Yi Wang^1*, Yifan Meng^2,11*, Wending Li^1*, Xiaofei Zhang³, Zaixing Deng⁴, Mengjun Hu⁵, Pingrong Shen⁶, Shengfeng Xu⁷, Chenglin Fu⁸, Wen Jiang⁹, Bing Wu¹⁰, Kezhen Li^2,11, Gang Chen^2,11, Juncheng Wei^2,11, Ling Xi^2,11, Junbo Hu¹¹, Xing Xie³, Ding Ma^2,11, Xiaodong Cheng^3✉, Peng Wu^2,11✉

1. School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
2. Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
3. Department of Gynecologic Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
4. Department of Obstetrics and Gynecology, Huzhou Maternity and Child Care Center, Huzhou, Zhejiang, China
5. Department of Obstetrics and Gynecology, Zhuji People's Hospital, Shaoxing, Zhejiang, China
6. Department of Obstetrics and Gynecology, Ninghai Maternity and Child Care Center, Ningbo, Zhejiang, China
7. Department of Obstetrics and Gynecology, Jiaxing Maternity and Child Care Center, Jiaxing, Zhejiang, China
8. Department of Obstetrics and Gynecology, Taizhou First People's Hospital, Taizhou, Zhejiang, China
9. Department of Obstetrics and Gynecology, Zhoushan Maternity and Child Care Center, Zhoushan, Zhejiang, China
10. Department of Obstetrics and Gynecology, Zhuji Maternity and Child Care Center, Shaoxing, Zhejiang, China
11. The Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education of China, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
*Co-first authors

✉ Corresponding authors: Peng Wu, Address: Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. The Key Laboratory of Cancer Invasion and Metastasis of the Min More

Citation:

Wang Y, Meng Y, Li W, Zhang X, Deng Z, Hu M, Shen P, Xu S, Fu C, Jiang W, Wu B, Li K, Chen G, Wei J, Xi L, Hu J, Xie X, Ma D, Cheng X, Wu P. Prevalence and Characteristics of hrHPV Infection among 414,540 Women: A Multicenter Study in Central and Eastern China. J Cancer 2019; 10(8):1902-1908. doi:10.7150/jca.30157. https://www.jcancer.org/v10p1902.htm

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Abstract

Objectives: Understanding the prevalence and characteristics of high-risk human papillomavirus (hrHPV) with the large-scale multicenter data based on a US FDA-approved testing method is important to guide ongoing vaccination programs in China.

Methods: We conducted a retrospective observational study based on data from 11 large hospitals in central and eastern China. From October 1st, 2012 to December 31st, 2016, a total of 480,034 cervical specimens were collected, and 414,540 eligible participants (14-80 years, mean age 39.9 years) were included and tested using Cervista High-Risk HPV Assay (Hologic Inc., Bedford, Mass, USA).

Results: The overall hrHPV prevalence in this study was 17.8% (73,713/414,540), with Wuhan slightly higher than Zhejiang (18.6% vs. 17.6%, P < 0.001). The prevalence showed a declining trend from 2012 to 2016. The most common hrHPV group was A9 (61.7%), followed by A5/A6 (29.4%) and A7 (25.6%). A U-shaped curve was observed for age-specific hrHPV prevalence: ≤19 years and ≥50 years were higher than other age groups.

Conclusion: In pre-vaccination period, A9 was the most dominant hrHPV group, and infections were most likely to occur at younger and older ages. The prevalence of hrHPV varied by cities and age groups, suggesting vaccination programs should be propagated in a population-specific approach.

Keywords: Cervista, China, distribution, high-risk human papillomavirus, multicenter, prevalence

Citation styles

APA

Wang, Y., Meng, Y., Li, W., Zhang, X., Deng, Z., Hu, M., Shen, P., Xu, S., Fu, C., Jiang, W., Wu, B., Li, K., Chen, G., Wei, J., Xi, L., Hu, J., Xie, X., Ma, D., Cheng, X., Wu, P. (2019). Prevalence and Characteristics of hrHPV Infection among 414,540 Women: A Multicenter Study in Central and Eastern China. Journal of Cancer, 10(8), 1902-1908. https://doi.org/10.7150/jca.30157.

ACS

Wang, Y.; Meng, Y.; Li, W.; Zhang, X.; Deng, Z.; Hu, M.; Shen, P.; Xu, S.; Fu, C.; Jiang, W.; Wu, B.; Li, K.; Chen, G.; Wei, J.; Xi, L.; Hu, J.; Xie, X.; Ma, D.; Cheng, X.; Wu, P. Prevalence and Characteristics of hrHPV Infection among 414,540 Women: A Multicenter Study in Central and Eastern China. J. Cancer 2019, 10 (8), 1902-1908. DOI: 10.7150/jca.30157.

NLM

CSE

Wang Y, Meng Y, Li W, Zhang X, Deng Z, Hu M, Shen P, Xu S, Fu C, Jiang W, Wu B, Li K, Chen G, Wei J, Xi L, Hu J, Xie X, Ma D, Cheng X, Wu P. 2019. Prevalence and Characteristics of hrHPV Infection among 414,540 Women: A Multicenter Study in Central and Eastern China. J Cancer. 10(8):1902-1908.

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