J Cancer 2018; 9(12):2072-2081. doi:10.7150/jca.23427

Review

Histone methylation in DNA repair and clinical practice: new findings during the past 5-years

Shuhua Wei1, Chunxiao Li1, Zhongnan Yin2, Jie Wen1, Hui Meng1, Lixiang Xue1,2,✉, Junjie Wang1,✉

1. Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China
2. Medical Research Center, Peking University Third Hospital, Beijing 100191, China

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Citation:
Wei S, Li C, Yin Z, Wen J, Meng H, Xue L, Wang J. Histone methylation in DNA repair and clinical practice: new findings during the past 5-years. J Cancer 2018; 9(12):2072-2081. doi:10.7150/jca.23427. Available from http://www.jcancer.org/v09p2072.htm

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Abstract

DNA double-strand breaks (DSBs) are highly toxic lesions that can impair cellular homeostasis and genome stability to result in tumorigenesis for inappropriate repair. Although DSBs are repaired by homologous recombination (HR) or non-homologous end-joining (NHEJ), the related mechanisms are still incompletely unclear. Indeed, more and more evidences indicate that the methylation of histone lysine has an important role in choosing the pathways of DNA repair. For example, tri-methylated H3K36 is required for HR repair, while di-methylated H4K20 can recruit 53BP1 for NHEJ repair. Here, we reviewed the recent progress in the molecular mechanisms by which histone methylation functions in DNA double-strand breaks repair (DSBR). The insight into the mechanisms of histone methylation repairing DNA damage will supply important cues for clinical cancer treatment.

Keywords: DNA repair, Double-Strand Breaks, Histone methylation.