J Cancer
2018; 9(9):1652-1659.
doi:10.7150/jca.24048 This issueCite
Review
Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions
Sheng Zhang1,2, Sanjun Cai1,2✉, Yanlei Ma1,2✉
1. Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. 2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
✉ Corresponding author: Dr. Yanlei Ma, Department of Colorectal Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'an Road, Shanghai, 20032, China, Tel.: +86 21 64175590; Fax: +86 21 54175590, E-mail: yanleimaedu.cn and Dr. Sanjun Cai, Department of Colorectal Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong'an Road, Shanghai, 20032, China, Tel.: +86 21 64175590; Fax: +86 21 54175590, E-mail: sanjuncaicomMore
Citation:
Zhang S, Cai S, Ma Y. Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions. J Cancer 2018; 9(9):1652-1659. doi:10.7150/jca.24048. https://www.jcancer.org/v09p1652.htm
The initiation and progression of colorectal cancer (CRC) involves genetic and epigenetic alterations influenced by dietary and environmental factors. Increasing evidence has linked the intestinal microbiota and colorectal cancer. More recently, Fusobacterium nucleatum (Fn), an opportunistic commensal anaerobe in the oral cavity, has been associated with CRC. Several research teams have reported an overabundance of Fn in human CRC and have elucidated the possible mechanisms by which Fn is involved in colorectal carcinogenesis in vitro and in mouse models. However, the mechanisms by which Fn promotes colorectal carcinogenesis remain unclear. To provide new perspectives for early diagnosis, the identification of high risk populations and treatment for colorectal cancer, this review will summarize the relative research progresses regarding the relationship between Fn and colorectal cancer.
Zhang, S., Cai, S., Ma, Y. (2018). Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions. Journal of Cancer, 9(9), 1652-1659. https://doi.org/10.7150/jca.24048.
ACS
Zhang, S.; Cai, S.; Ma, Y. Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions. J. Cancer 2018, 9 (9), 1652-1659. DOI: 10.7150/jca.24048.
NLM
Zhang S, Cai S, Ma Y. Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions. J Cancer 2018; 9(9):1652-1659. doi:10.7150/jca.24048. https://www.jcancer.org/v09p1652.htm
CSE
Zhang S, Cai S, Ma Y. 2018. Association between Fusobacterium nucleatum and colorectal cancer: Progress and future directions. J Cancer. 9(9):1652-1659.
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