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J Cancer 2017; 8(17):3592-3597. doi:10.7150/jca.21556 This issue Cite

Research Paper

Clinicopathological Characteristics and Prognosis of Ossifying Fibroma in the Jaws of Children: A Retrospective Study

Ying Liu¹, Xiao-Feng Shan¹, Xue-Sheng Guo^1,2, Shang Xie^1✉, Zhi-Gang Cai^1✉

1. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, 22# Zhongguancun South Avenue, Haidian District, Beijing, 100081, China;
2. Department of Stomatology, Capital Medical University Pinggu Teaching Hospital, Beijing 101200, China.

✉ Corresponding authors: Zhi-Gang Cai, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, 22# Zhongguancun South Avenue, Haidian District, Beijing, 100081, China. Email: c2013xscom, Tel: +86 010 82195956, Fax: +86 010 62173402; or Shang Xie, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, 22# Zhongguancun South Avenue, Haidian District, Beijing, 100081, China. Email: xs2013pku.edu.cn, Tel: +86 010 82195158, Fax: +86 010 62173402. More

Abstract

BACKGROUND: Ossifying fibroma in the jaws is a benign tumor and easily recurs in children, of which the treatment methods and prognosis still remain controversial. In this study, we aimed to review the clinicopathological characteristics, treatment, and prognosis of ossifying fibroma in the jaws of children, and offer recommendations for clinical decision-making.

METHODS: A retrospective study was carried out on patients below the age of 18 years with ossifying fibroma in the jaws. Patients with complete clinical, pathological, and radiological records were included and followed-up.

RESULTS: Sixty-three cases were collected with a preliminary search. After screening, fifty patients were included for general information analysis, of which forty-two patients were included in the recurrence analysis. Twelve patients showed a relapse, with a recurrence rate of 28.6% (12/42). The recurrence rates in cases with different surgical approaches and different X-ray boundaries were statistically different. Besides, twenty-three patients underwent reconstruction by free tissue grafting and the success rate was 96% (22/23).

CONCLUSIONS: There was significant difference in the recurrence rates among different X-ray manifestations and surgical methods. An extended resection and reconstruction with free tissue grafting was a reliable method with a 96% success rate.

Keywords: children, ossifying fibroma, treatment, relapse, reconstruction.

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