J Cancer 2017; 8(12):2319-2327. doi:10.7150/jca.19079
Epithelial-mesenchymal transition: potential regulator of ABC transporters in tumor progression
1. School of Pharmacy, Fujian Medical University, Fuzhou, China
2. Molecular Biology Laboratory of Traditional Chinese Medicine, Fujian Provincial Hospital, Clinical College of Fujian Medical University, Fuzhou, China
Jiang ZS, Sun YZ, Wang SM, Ruan JS. Epithelial-mesenchymal transition: potential regulator of ABC transporters in tumor progression. J Cancer 2017; 8(12):2319-2327. doi:10.7150/jca.19079. Available from http://www.jcancer.org/v08p2319.htm
Epithelial-mesenchymal transition (EMT) can directly contribute to some malignant phenotypes of tumor cells including invasion, metastasis and resistance to chemotherapy. Although EMT is widely demonstrated to play a critical role in chemoresistance and metastasis, the potential signaling network between EMT and drug resistance is still unclear. The distribution of drugs in the internal and external environment of the tumor cells is tightly linked with ATP-binding cassette (ABC) transporters. Recent studies have shown that ABC transporters expression changed continuously during EMT. We believe that EMT is an important regulator of ABC transporters. In this review, we discuss how EMT regulates ABC transporters and their potential linkages. And we hope the knowledge of EMT and ABC transporters will offer more effective targets to experimental research.
Keywords: ABC transporters, EMT, CSCs, resistance, TFs, miRNA