J Cancer 2017; 8(5):716-729. doi:10.7150/jca.17779


The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression

Anna Tyutyunnykova1, Gennady Telegeev2, Anna Dubrovska1, 3, 4 ✉

1. OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstrasse 74, 01307 Dresden, Germany.
2. The Institute of Molecular Biology and Genetics of NASU, Kyiv, Ukraine.
3. German Cancer Consortium (DKTK), Dresden, Germany.
4. Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.

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Tyutyunnykova A, Telegeev G, Dubrovska A. The controversial role of phospholipase C epsilon (PLCε) in cancer development and progression. J Cancer 2017; 8(5):716-729. doi:10.7150/jca.17779. Available from http://www.jcancer.org/v08p0716.htm

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The phospholipase C (PLC) enzymes are important regulators of membrane phospholipid metabolism. PLC proteins can be activated by the receptor tyrosine kinases (RTK) or G-protein coupled receptors (GPCR) in response to the different extracellular stimuli including hormones and growth factors. Activated PLC enzymes hydrolyze phosphoinositides to increase the intracellular level of Ca2+ and produce diacylglycerol, which are important mediators of the intracellular signaling transduction. PLC family includes 13 isozymes belonging to 6 subfamilies according to their domain structures and functions. Although importance of PLC enzymes for key cellular functions is well established, the PLC proteins belonging to the ε, ζ and η subfamilies were identified and characterized only during the last decade. As a largest known PLC protein, PLCε is involved in a variety of signaling pathways and controls different cellular properties. Nevertheless, its role in carcinogenesis remains elusive.

The aim of this review is to provide a comprehensive and up-to-date overview of the experimental and clinical data about the role of PLCε in the development and progression of the different types of human and experimental tumors.

Keywords: Phospholipase Cε, cancer development, intracellular signaling, oncogene, tumor suppressor