J Cancer 2017; 8(4):531-536. doi:10.7150/jca.17519
Association of Genetic Polymorphisms in the LncRNAs with Gastric Cancer Risk in a Chinese Population
1. General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;
2. Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;
3. Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
*These authors contributed equally to this work.
He BS, Sun HL, Xu T, Pan YQ, Lin K, Gao TY, Zhang ZY, Wang SK. Association of Genetic Polymorphisms in the LncRNAs with Gastric Cancer Risk in a Chinese Population. J Cancer 2017; 8(4):531-536. doi:10.7150/jca.17519. Available from http://www.jcancer.org/v08p0531.htm
Background: Genome-wide association studies have identified that polymorphisms in 8q24 confer susceptibility to gastric cancer. Polymorphisms in the lncRNA PRNCR1, PCAT1, and CCAT2 transcribed from the 8q24 locus have a potential risk for gastric cancer.
Methods: To evaluate whether there is such an association in Chinese population, a case-control study enrolled 494 patients and 494 healthy controls was carried out. Sequenom MassARRAY platform was used for genotyping.
Results: This study showed that rs16901946 G allele was associated with increased risk of gastric cancer (AG: adjusted OR = 1.33, 95% CI =1.02-1.73, p=0.033; GG: adjusted OR = 2.07; 95% CI = 1.11-3.86, p=0.023, AG/GG: adjusted OR = 1.39, 95% CI = 1.08-1.1.79, p=0.011; additive model: adjusted OR = 1.37; 95% CI = 1.10-1.70, p=0.004). Stratified analysis revealed that the increased risk was more evident in the cohort of younger subjects (adjusted OR = 1.84, 95% CI = 1.18-2.87, p=0.007), males (adjusted OR = 1.55, 95% CI = 1.15-2.08, p=0.004), positive Helicobacter pylori infection (adjusted OR = 1.44, 95% CI = 1.02-2.03, p=0.041), gastric cardia adenocarcinoma (adjusted OR = 1.61, 95% CI = 1.10-2.35, p=0.014), and tumor stage T1-T2 (adjusted OR = 1.58, 95% CI = 1.10-2.28, p=0.013).
Conclusions: Our study suggested that rs16901946 G allele carriers have an increased risk of gastric cancer, and the risk could be enhanced by the interactions between the polymorphism and age, sex, Helicobacter pylori infection.
Keywords: Gastric cancer, polymorphism, lncRNA.