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J Cancer 2016; 7(9):1174-1180. doi:10.7150/jca.15243 This issue Cite

Research Paper

Prognostic Model to Predict Survival Outcome for Curatively Resected Liposarcoma: A Multi-Institutional Experience

Yoon Jung Oh^1*, Seong Yoon Yi^2*, Ki Hyang Kim³, Yong Jin Cho⁴, Seung Hoon Beum⁵, Young Han Lee⁶, Jin-Suck Suh⁶, Hyuk Hur⁷, Kyung Sik Kim⁷, Sung Hoon Kim⁸, Young Deuk Choi⁹, Kyoo-Ho Shin⁴, Hyun Jung Jun¹⁰, Sung Joo Kim¹¹, Jeeyun Lee¹², Se Hoon Park¹², Sung Hoon Noh⁷, Sun Young Rha⁵, Hyo Song Kim^5✉

1. Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea;
2. Division of Hematology-Oncology, Department of Internal Medicine, Inje University Ilsan Paik Hospital; Ilsan, Korea;
3. Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea;
4. Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Korea;
5. Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea;
6. Department of Radiology, Yonsei University College of Medicine, Seoul, Korea;
7. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea;
8. Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea;
9. Department of Urology, Yonsei University College of Medicine, Seoul, Korea;
10. Division of Medical Oncology & Hematology, Department of Internal Medicine, Seoul Medical Center, Seoul, Korea;
11. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;
12. Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
*Yoon Jung Oh and Seong Yoon Yi equally contributed to this work as first authors.

✉ Corresponding author: Hyo Song Kim, M.D., Ph.D. Yonsei Cancer Center, Yonsei University Health System, 50 Yonsei‑ro, Seodaemun‑gu Seoul, Republic of Korea, 120-752.

Abstract

Purpose: We performed this study to analyze the clinical features and prognosis of Korean patients with liposarcoma.

Patients & Methods: Between October 1986 and April 2013, 231 patients who were diagnosed with liposarcoma by histologic examination were enrolled in this study.

Results: The distribution of histologic subtypes was well-differentiated (n = 97, 42%), myxoid (n = 74, 32%), dedifferentiated (n = 32, 13.9%), pleomorphic (n = 15, 6.5%), and round-cell liposarcoma (n = 13, 5.6%). The majority of liposarcomas were located in the lower extremities (35.5%) and retroperitoneum (34.2%). Prognosis was worse for the trunk group compared with the extremity group (median disease-free survival [DFS] 3.3 vs. 9.9 years, respectively, P <0.001). Median DFS was significantly worse in patients with high grade histology compared to those with low grade histology (16.9% vs. 65.7%, P <0.001). The independent prognostic factors associated with survival were histology (hazard ratio [HR] 3.01; 95% confidence interval [CI], 1.82-4.97; P <0.001) and primary site (HR 1.80; 95% CI, 1.12-2.89; P = 0.015). Three risk groups with different survival outcomes were identified: group 1 (n = 98), no risk factors; group 2 (n = 92), one risk factor; and group 3 (n = 41), two risk factors.

Conclusions: Histologic subtype and primary site were independent prognostic factors for curatively resected liposarcoma. A prognostic model for patients with liposarcoma clarified distinct groups of patients with good prognostic discrimination.

Keywords: Liposarcoma, Asian, Prognostic model, Survival.

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