Modulation of immune-responses by DSF/Cu enhances the anti-tumor effects of DTX for metastasis breast cancer

Guo, Jingtian; Ma, Yuxiao; Tang, Tiejun; Bian, Zhengying; Li, Qianwen; Tang, Lei; Li, Zhuolan; Li, Mengyuan; Wang, Liming; Zeng, Aizhong; Huang, Shihao; Guo, Wei

doi:10.7150/jca.89120

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2024; 15(6):1523-1535. doi:10.7150/jca.89120 This issue Cite

Research Paper

Modulation of immune-responses by DSF/Cu enhances the anti-tumor effects of DTX for metastasis breast cancer

Jingtian Guo^*, Yuxiao Ma^*, Tiejun Tang, Zhengying Bian, Qianwen Li, Lei Tang, Zhuolan Li, Mengyuan Li, Liming Wang, Aizhong Zeng, Shihao Huang, Wei Guo^✉

Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, PR China.
* These authors contributed equally to this work.

Citation:

Guo J, Ma Y, Tang T, Bian Z, Li Q, Tang L, Li Z, Li M, Wang L, Zeng A, Huang S, Guo W. Modulation of immune-responses by DSF/Cu enhances the anti-tumor effects of DTX for metastasis breast cancer. J Cancer 2024; 15(6):1523-1535. doi:10.7150/jca.89120. https://www.jcancer.org/v15p1523.htm

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Abstract

Metastasis has been one of the most important causes of death from breast cancer, and chemotherapy remains the major option for metastatic breast cancer. However, drug resistance and higher toxicity from chemotherapy have been an obstacle for clinical practice, and the combination of chemotherapy with immunotherapy has emerged as a promising treatment strategy. Here, we describe a therapy based on the combination of disulfiram (DSF) and Cu²⁺ with widely used cytotoxic docetaxel (DTX). DSF/Cu-induced immunogenic cell death promoted the release of type I interferon and human monocyte-induced dendritic cell maturation, which established a foundation for the combination with chemotherapy. Consequently, the combination of DSF/Cu and DTX resulted in significantly more potent anti-tumor effects in 4T1-bearing mice than in single therapy. The present study has shed new light on combining DSF/Cu-induced immune responses with traditional chemotherapeutic agents to achieve greater benefits for patients with metastasis.

Keywords: metastasis breast cancer, immunogenic cell death, disulfiram

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APA

Guo, J., Ma, Y., Tang, T., Bian, Z., Li, Q., Tang, L., Li, Z., Li, M., Wang, L., Zeng, A., Huang, S., Guo, W. (2024). Modulation of immune-responses by DSF/Cu enhances the anti-tumor effects of DTX for metastasis breast cancer. Journal of Cancer, 15(6), 1523-1535. https://doi.org/10.7150/jca.89120.

ACS

Guo, J.; Ma, Y.; Tang, T.; Bian, Z.; Li, Q.; Tang, L.; Li, Z.; Li, M.; Wang, L.; Zeng, A.; Huang, S.; Guo, W. Modulation of immune-responses by DSF/Cu enhances the anti-tumor effects of DTX for metastasis breast cancer. J. Cancer 2024, 15 (6), 1523-1535. DOI: 10.7150/jca.89120.

NLM

CSE

Guo J, Ma Y, Tang T, Bian Z, Li Q, Tang L, Li Z, Li M, Wang L, Zeng A, Huang S, Guo W. 2024. Modulation of immune-responses by DSF/Cu enhances the anti-tumor effects of DTX for metastasis breast cancer. J Cancer. 15(6):1523-1535.

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