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J Cancer 2023; 14(18):3416-3428. doi:10.7150/jca.88964 This issue Cite

Research Paper

Overexpression of FNDC4 constrains ovarian cancer progression by promoting cell apoptosis and inhibiting cell growth

Ningxin Li1, Huan Li1, Shufen Zhou1, Qingyu Zhang1, Guangtao Li1, Huanfa Yi1, Yahui Liu2✉, Zhanchuan Ma1✉

1. Central Laboratory, Lequn Branch, The First Hospital of Jilin University, Changchun, Jilin, China.
2. Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, 130000, China.

✉ Corresponding author: Yahui Liu, Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, 130000, China; E-mail: yahuiedu.cn; Zhanchuan Ma, Central Laboratory, The First Hospital of Jilin University More

Citation:
Li N, Li H, Zhou S, Zhang Q, Li G, Yi H, Liu Y, Ma Z. Overexpression of FNDC4 constrains ovarian cancer progression by promoting cell apoptosis and inhibiting cell growth. J Cancer 2023; 14(18):3416-3428. doi:10.7150/jca.88964. https://www.jcancer.org/v14p3416.htm
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Abstract

Graphic abstract

Hepatocellular carcinoma is one of the most common malignant tumors in the world. It has been reported that fibronection type III domain containing family plays an important role in the formation and development of a variety of tumors, but the role of FNDC4 is still unclear. In our study, we found that FNDC4 was highly expressed in normal liver tissues but abnormally expressed at low levels in liver cancer tissues. Enhanced apoptosis and decreased proliferation were shown in the FNDC4 overexpression model in HepG2 cells. In addition, FNDC4 was negatively correlated with AFP, a tumor marker of HCC, and other cancer-related genes such as AHSA1, GDF1, GPC3 and MDK. In addition, we found that FNDC4 was associated with the abundance of several tumor-infiltrating lymphocytes and the expression of chemokines and immunostimulators, and FNDC4 was enriched in response to transforming growth factor β. These results indicated that FNDC4 plays a key role in hepatocellular carcinoma progression and might be a promising biomarker for cancer diagnosis.

Keywords: FNDC4, hepatocellular carcinoma, tumor suppressor, prognosis evaluation, bioinformatics analysis.

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APA
Li, N., Li, H., Zhou, S., Zhang, Q., Li, G., Yi, H., Liu, Y., Ma, Z. (2023). Overexpression of FNDC4 constrains ovarian cancer progression by promoting cell apoptosis and inhibiting cell growth. Journal of Cancer, 14(18), 3416-3428. https://doi.org/10.7150/jca.88964.

ACS
Li, N.; Li, H.; Zhou, S.; Zhang, Q.; Li, G.; Yi, H.; Liu, Y.; Ma, Z. Overexpression of FNDC4 constrains ovarian cancer progression by promoting cell apoptosis and inhibiting cell growth. J. Cancer 2023, 14 (18), 3416-3428. DOI: 10.7150/jca.88964.

NLM
Li N, Li H, Zhou S, Zhang Q, Li G, Yi H, Liu Y, Ma Z. Overexpression of FNDC4 constrains ovarian cancer progression by promoting cell apoptosis and inhibiting cell growth. J Cancer 2023; 14(18):3416-3428. doi:10.7150/jca.88964. https://www.jcancer.org/v14p3416.htm

CSE
Li N, Li H, Zhou S, Zhang Q, Li G, Yi H, Liu Y, Ma Z. 2023. Overexpression of FNDC4 constrains ovarian cancer progression by promoting cell apoptosis and inhibiting cell growth. J Cancer. 14(18):3416-3428.

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