CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas

Wu, Zhiqiang; Deng, Liyuan; Tao, Jin; Lu, Yuhai; Zeng, Xiaofei; Jia, Weikun; Chen, Hu

doi:10.7150/jca.87983

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J Cancer 2023; 14(17):3238-3247. doi:10.7150/jca.87983 This issue Cite

Research Paper

CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas

Zhiqiang Wu^*, Liyuan Deng^*, Jin Tao^*, Yuhai Lu, Xiaofei Zeng, Weikun Jia, Hu Chen^✉

Department of Cardiothoracic Surgery, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, China.
*The authors contributed equally to this manuscript.

Citation:

Wu Z, Deng L, Tao J, Lu Y, Zeng X, Jia W, Chen H. CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas. J Cancer 2023; 14(17):3238-3247. doi:10.7150/jca.87983. https://www.jcancer.org/v14p3238.htm

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Abstract

Chaperonins, which contain t-complex polypeptide 1 (CCT), are critical for correct protein folding to generate stable and functional protein conformations, which are important for cell growth and survival. However, little is known about the expression and prognostic significance of CCT8 (subunit 8 of the CCT complex chaperonin) in lung cancer. In this study, we demonstrated that CCT8 expression is frequently increased in human lung cancer. Survival analysis indicated that CCT8 expression is closely correlated with inferior overall survival in lung adenocarcinoma (LUAD), but not in lung squamous carcinoma (LUSC). Subsequently, ectopic expression of CCT8 facilitated cell migration and tumor metastasis, and vice versa. Mechanistically, CCT8 interacted and activated ATK. Inhibition of AKT suppressed CCT8-induced cell migration and tumor metastasis. Our findings support CCT8 as a biomarker for LUAD prognosis and as a target for LUAD therapy.

Keywords: LUAD, CCT8, AKT, Cell migration, Tumor metastasis

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APA

Wu, Z., Deng, L., Tao, J., Lu, Y., Zeng, X., Jia, W., Chen, H. (2023). CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas. Journal of Cancer, 14(17), 3238-3247. https://doi.org/10.7150/jca.87983.

ACS

Wu, Z.; Deng, L.; Tao, J.; Lu, Y.; Zeng, X.; Jia, W.; Chen, H. CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas. J. Cancer 2023, 14 (17), 3238-3247. DOI: 10.7150/jca.87983.

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CSE

Wu Z, Deng L, Tao J, Lu Y, Zeng X, Jia W, Chen H. 2023. CCT8 promotes cell migration and tumor metastasis in lung adenocarcinomas. J Cancer. 14(17):3238-3247.

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