Lipid metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy

Liu, Hui; Li, Xiuming; Dong, Yajie; Zhou, Changhua; Rezeng, Caidan

doi:10.7150/jca.86683

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International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2023; 14(11):2066-2074. doi:10.7150/jca.86683 This issue Cite

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Lipid metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy

Hui Liu^1†, Xiuming Li^2†, Yajie Dong¹, Changhua Zhou³, Caidan Rezeng^4,5✉

1. Chengde Medical University, Chengde, China, Hebei 067000, China.
2. Department of Urology, Affiliated Hospital of Chengde Medical University, Hebei 067000, China.
3. Department of Pediatrics, Chengde County Hospital of Traditional Chinese Medicine, Hebei 067000, China.
4. School of Pharmacy, Qinghai University for Nationalities, Qinghai, 810000, China.
5. Engineering Research Center for Pharmaceutics of Chinese Materia Medica and New Drug Development, Ministry of Education, Beijing 100029, China.
†These authors have contributed equally to this work.

Citation:

Liu H, Li X, Dong Y, Zhou C, Rezeng C. Lipid metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy. J Cancer 2023; 14(11):2066-2074. doi:10.7150/jca.86683. https://www.jcancer.org/v14p2066.htm

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Abstract

Epidemiological data have shown a positive correlation between lipid levels and tumor occurrence, such as the correlation between tumor frequency and aggressiveness, and cardiovascular disease, obesity, type 2 diabetes mellitus, and hyperinsulinemia. Therefore, reducing fat accumulation or weakening lipid metabolism may affect the carcinogenic processes of cells. Many studies have shown that traditional Chinese Medicine (TCM) has obvious advantages over traditional therapies in terms of fewer side effects, lower toxicity, and lower economic burden. This paper reviews the mechanism by which TCM regulates lipid metabolism and its antitumor effect through this regulation, with the aim of elucidating the bioactive compounds in TCM with good efficacy and few side effects that can provide promising therapeutic drugs for targeting lipid metabolism reprogramming in cancer.

Keywords: Traditional Chinese medicine, TCM, tumor, lipid metabolism reprogramming, cancer therapy

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APA

Liu, H., Li, X., Dong, Y., Zhou, C., Rezeng, C. (2023). Lipid metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy. Journal of Cancer, 14(11), 2066-2074. https://doi.org/10.7150/jca.86683.

ACS

Liu, H.; Li, X.; Dong, Y.; Zhou, C.; Rezeng, C. Lipid metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy. J. Cancer 2023, 14 (11), 2066-2074. DOI: 10.7150/jca.86683.

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CSE

Liu H, Li X, Dong Y, Zhou C, Rezeng C. 2023. Lipid metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy. J Cancer. 14(11):2066-2074.

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