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J Cancer 2022; 13(14):3526-3532. doi:10.7150/jca.67534 This issue Cite

Research Paper

Detection of Kita-Kyushu Lung Cancer Antigen-1, a Cancer/Testis Antigen, in the Stomach Close to a Cancerous Condition

Toshikazu Otsuka1#, Takashi Fukuyama2✉#, Nobue Futawatari3, Kumiko Tahara1, Masaaki Watanabe1, Yoshinobu Ichiki4, Takafumi Soeno5, Yoshihito Takahashi5, Hitoshi Yamazaki6, Yuma Fujimori7, Taichi Ohshiro7, Noritada Kobayashi2, Mitsuhiro Kida8, Wasaburo Koizumi8, Chika Kusano8

1. Division of Internal Medicine, Kitasato University Medical Centre, Kitamoto, Saitama, Japan.
2. Division of Biomedical Research, Kitasato University Medical Centre, Kitamoto, Saitama, Japan.
3. Division of General and Gastroenterological Surgery, Department of Surgery (Ohashi), Toho University, Tokyo, Japan.
4. Department of General Thoracic Surgery, National Hospital Organization, Saitama Hospital, Wako, Saitama, Japan.
5. Division of Surgery, Kitasato University Medical Centre, Kitamoto, Saitama, Japan.
6. Division of Pathology, Kitasato University Medical Centre, Kitamoto, Saitama, Japan.
7. Department of Microbial Chemistry and Medicinal Research Laboratories, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
8. Department of Gastroenterology, School of Medicine, Kitasato University, Sagamihara, Japan.
#Equal contributors to the manuscript.

✉ Corresponding author: Dr. Takashi Fukuyama, Division of Biomedical Research, Kitasato University Medical Centre, 6-100 Arai, Kitamoto, Saitama 364-8501, Japan. Tel: +81-48-593-1236; Fax: +81-48-593-1262; E-mail: fukuyamkitasato-u.ac.jp.

Citation:
Otsuka T, Fukuyama T, Futawatari N, Tahara K, Watanabe M, Ichiki Y, Soeno T, Takahashi Y, Yamazaki H, Fujimori Y, Ohshiro T, Kobayashi N, Kida M, Koizumi W, Kusano C. Detection of Kita-Kyushu Lung Cancer Antigen-1, a Cancer/Testis Antigen, in the Stomach Close to a Cancerous Condition. J Cancer 2022; 13(14):3526-3532. doi:10.7150/jca.67534. https://www.jcancer.org/v13p3526.htm
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Abstract

Graphic abstract

Background: Kita-Kyushu lung cancer antigen-1 (KK-LC-1), encoded by CT83, is a cancer/testis antigen (CTA) and an attractive target for immunotherapy. Our previous study demonstrated frequent CT83 expression in gastric cancers (GCs) and non-tumor sites of the stomach with tumors. Additionally, there was a correlation with Helicobacter pylori (Hp) infection. Since it currently remains unclear whether KK-LC-1 is expressed in the stomach without GC, this study investigated KK-LC-1 expression in non-GC stomach.

Methods: We investigated differences in CT83 gene expression at non-tumor sites of stomachs with or without tumors in 118 GC patients and 115 non-GC patients. Fisher's exact test was used for statistical analyses.

Results: CT83 expression was detected in 77% of non-tumor sites in stomachs with tumors, which was significantly higher than in stomachs without tumors (7%, p < 0.0001). All patients with CT83 expression at non-tumor sites of their stomachs without tumors carried Hp.

Conclusion: CT83 appears to be rarely expressed in the atrophic stomach, and furthermore, a part of patients positive for its expression will develop GC in the future, suggesting that CT83 expression is a useful marker for predicting GC.

Keywords: gastric cancer, Helicobacter pylori, atrophic gastritis, Kita-Kyushu lung cancer antigen-1

Citation styles

APA
Otsuka, T., Fukuyama, T., Futawatari, N., Tahara, K., Watanabe, M., Ichiki, Y., Soeno, T., Takahashi, Y., Yamazaki, H., Fujimori, Y., Ohshiro, T., Kobayashi, N., Kida, M., Koizumi, W., Kusano, C. (2022). Detection of Kita-Kyushu Lung Cancer Antigen-1, a Cancer/Testis Antigen, in the Stomach Close to a Cancerous Condition. Journal of Cancer, 13(14), 3526-3532. https://doi.org/10.7150/jca.67534.

ACS
Otsuka, T.; Fukuyama, T.; Futawatari, N.; Tahara, K.; Watanabe, M.; Ichiki, Y.; Soeno, T.; Takahashi, Y.; Yamazaki, H.; Fujimori, Y.; Ohshiro, T.; Kobayashi, N.; Kida, M.; Koizumi, W.; Kusano, C. Detection of Kita-Kyushu Lung Cancer Antigen-1, a Cancer/Testis Antigen, in the Stomach Close to a Cancerous Condition. J. Cancer 2022, 13 (14), 3526-3532. DOI: 10.7150/jca.67534.

NLM
Otsuka T, Fukuyama T, Futawatari N, Tahara K, Watanabe M, Ichiki Y, Soeno T, Takahashi Y, Yamazaki H, Fujimori Y, Ohshiro T, Kobayashi N, Kida M, Koizumi W, Kusano C. Detection of Kita-Kyushu Lung Cancer Antigen-1, a Cancer/Testis Antigen, in the Stomach Close to a Cancerous Condition. J Cancer 2022; 13(14):3526-3532. doi:10.7150/jca.67534. https://www.jcancer.org/v13p3526.htm

CSE
Otsuka T, Fukuyama T, Futawatari N, Tahara K, Watanabe M, Ichiki Y, Soeno T, Takahashi Y, Yamazaki H, Fujimori Y, Ohshiro T, Kobayashi N, Kida M, Koizumi W, Kusano C. 2022. Detection of Kita-Kyushu Lung Cancer Antigen-1, a Cancer/Testis Antigen, in the Stomach Close to a Cancerous Condition. J Cancer. 13(14):3526-3532.

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