J Cancer 2022; 13(8):2430-2439. doi:10.7150/jca.71619 This issue


Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer

Gaoxuan Shao1, Yufan Qian1, Lu Lu1, Ying Liu1, Tao Wu2, Guang Ji1✉, Hanchen Xu1✉

1. Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine - Shanghai 200032, China.
2. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

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Shao G, Qian Y, Lu L, Liu Y, Wu T, Ji G, Xu H. Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer. J Cancer 2022; 13(8):2430-2439. doi:10.7150/jca.71619. Available from https://www.jcancer.org/v13p2430.htm

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Graphic abstract

Lysophosphatidylcholine acyltransferases (LPCATs) are among the lysophopholipid acyltransferases (LPLATs) that specifically regulate the abundance of different phosphatidylcholine (PC) species in a variety of cell and tissue types, thereby playing an important role in lipid metabolism and homeostasis. Lysophosphatidylcholine acyltransferase 3 (LPCAT3, MBOAT5) is a member of the LPCAT family that primarily regulates the levels of arachidonic PC species. LPCAT3 is regulated by the liver X receptor, which plays an important role in lipoprotein production in the liver and small intestine. Increasing lines of research have demonstrated that LPCAT3 plays important roles in the occurrence and development of many diseases, such as atherosclerosis, intestinal tumors, and nonalcoholic steatohepatitis (NASH). The development of many diseases has been linked to the proinflammatory effects of LPCAT3. This review focuses on the current knowledge of LPCAT3, including its function and mechanism in different diseases. We aim to provide a comprehensive and in-depth understanding of LPCAT3 and to provide new ideas for the treatment of some diseases.

Keywords: Lysophosphatidylcholine acyltransferase 3, Phosphatidylcholine, Atherosclerosis, Inflammation, Nonalcoholic steatohepatitis, Cancer