Association between Platelet Count with 1-year Survival in Patients with Cancer Cachexia

Liu, Yuying; Ge, Yizhong; Li, Qinqin; Ruan, Guotian; Zhang, Qi; Zhang, Xi; Tang, Meng; Song, Mengmeng; Zhang, Xiaowei; Li, Xiangrui; Zhang, Kangping; Yang, Ming; Hu, Chunlei; Liu, Tong; Xie, Hailun; Chen, Yongbing; Yu, Kaiying; Cong, Minghua; Li, Wei; Wang, Zhengping; Shi, Hanping

doi:10.7150/jca.62788

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International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2021; 12(24):7436-7444. doi:10.7150/jca.62788 This issue Cite

Research Paper

Association between Platelet Count with 1-year Survival in Patients with Cancer Cachexia

Yuying Liu^1,2*, Yizhong Ge^2,3,4*, Qinqin Li^1,2,3*, Guotian Ruan^2,3, Qi Zhang^2,3, Xi Zhang^2,3, Meng Tang^2,3, Mengmeng Song^2,3, Xiaowei Zhang^2,3, Xiangrui Li^2,3, Kangping Zhang^2,3, Ming Yang^2,3, Chunlei Hu^2,3, Tong Liu^2,3, Hailun Xie^2,3, Yongbing Chen^2,3, Kaiying Yu^2,3, Minghua Cong⁵, Wei Li⁶, Zhengping Wang^1✉, Hanping Shi^2,3✉

1. Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252000, China.
2. Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
3. Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, 100038, China.
4. The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
5. Comprehensive Oncology Department, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100038, China.
6. Cancer Center, the First Hospital, Jilin University, Changchun, 130021, China.
*Equal contributions to this work with shared first authorship.

✉ Corresponding authors: Prof. Han-Ping Shi, Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University; Beijing International Science and Technology Cooperation Base for Cancer Metab More

Citation:

Liu Y, Ge Y, Li Q, Ruan G, Zhang Q, Zhang X, Tang M, Song M, Zhang X, Li X, Zhang K, Yang M, Hu C, Liu T, Xie H, Chen Y, Yu K, Cong M, Li W, Wang Z, Shi H. Association between Platelet Count with 1-year Survival in Patients with Cancer Cachexia. J Cancer 2021; 12(24):7436-7444. doi:10.7150/jca.62788. https://www.jcancer.org/v12p7436.htm

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Abstract

Background: Changes in platelet count (PLT) are strongly associated with patient survival and may be clinically indicative of certain underlying diseases. However, there were few studies on the prognosis of patients with cancer cachexia.

Objective: The purpose of this study was to investigate the relationship between PLT and 1-year survival in patients with cancer cachexia.

Methods: We performed a nested case-control study of data from a multicenter clinical study of cancer. There were 252 patients with cancer cachexia whose survival time was less than or equal to 1 year and 252 patients with cancer cachexia whose survival time was more than 1 year meeting the inclusion criteria. The mortality risk and the adjusted risk were estimated by logistic regression and displayed as odds ratios (ORs) and 95% confidence intervals (95% CIs).

Results: PLT was negatively correlated with 1-year overall survival (OS) of patients with cancer cachexia (increased per standard deviation (SD): OR = 1.29; 95% CI: 1.05-1.60; P = 0.018). The higher the PLT, the lower the OS of patients. When classified by dichotomy (D1 < 296×10⁹/L, D2 ≥ 296×10⁹/L), OS of patients in the D2 group was worse (OR = 2.18; 95% CI: 1.38-3.47; P = 0.001). When classified by quartile (Q1- Q3 < 305×10⁹/L, Q4 ≥ 305×10⁹/L), OS of patients in the Q4 group was poorer (OR = 1.82; 95% CI: 1.14-2.94; P = 0.013). In addition, patients with a low PLT (< 296×10⁹/L) and either a high total bilirubin (TBIL) (≥ 17.1 µmol/L) or a smoking history had poor 1-year survival. Based on our primary cohort study, we conducted a survival analysis of 3130 patients with cancer cachexia and found that OS was better in patients with low PLT (< 296×10⁹/L).

Conclusion: PLT was negatively correlated with 1-year overall survival of patients with cancer cachexia.

Keywords: platelet count, survival, cancer cachexia, nested case-control study

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APA

Liu, Y., Ge, Y., Li, Q., Ruan, G., Zhang, Q., Zhang, X., Tang, M., Song, M., Zhang, X., Li, X., Zhang, K., Yang, M., Hu, C., Liu, T., Xie, H., Chen, Y., Yu, K., Cong, M., Li, W., Wang, Z., Shi, H. (2021). Association between Platelet Count with 1-year Survival in Patients with Cancer Cachexia. Journal of Cancer, 12(24), 7436-7444. https://doi.org/10.7150/jca.62788.

ACS

Liu, Y.; Ge, Y.; Li, Q.; Ruan, G.; Zhang, Q.; Zhang, X.; Tang, M.; Song, M.; Zhang, X.; Li, X.; Zhang, K.; Yang, M.; Hu, C.; Liu, T.; Xie, H.; Chen, Y.; Yu, K.; Cong, M.; Li, W.; Wang, Z.; Shi, H. Association between Platelet Count with 1-year Survival in Patients with Cancer Cachexia. J. Cancer 2021, 12 (24), 7436-7444. DOI: 10.7150/jca.62788.

NLM

CSE

Liu Y, Ge Y, Li Q, Ruan G, Zhang Q, Zhang X, Tang M, Song M, Zhang X, Li X, Zhang K, Yang M, Hu C, Liu T, Xie H, Chen Y, Yu K, Cong M, Li W, Wang Z, Shi H. 2021. Association between Platelet Count with 1-year Survival in Patients with Cancer Cachexia. J Cancer. 12(24):7436-7444.

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