Insights into the role of ERp57 in cancer

Song, Danyang; Liu, Hao; Wu, Jian; Gao, Xiaoliang; Hao, Jianyu; Fan, Daiming

doi:10.7150/jca.48707

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J Cancer 2021; 12(8):2456-2464. doi:10.7150/jca.48707 This issue Cite

Review

Insights into the role of ERp57 in cancer

Danyang Song¹, Hao Liu², Jian Wu², Xiaoliang Gao², Jianyu Hao^1✉, Daiming Fan^1,2✉

1. Department of Gastroenterology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
2. State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Military Medical University, Xi'an 710032, China.

Citation:

Song D, Liu H, Wu J, Gao X, Hao J, Fan D. Insights into the role of ERp57 in cancer. J Cancer 2021; 12(8):2456-2464. doi:10.7150/jca.48707. https://www.jcancer.org/v12p2456.htm

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Abstract

Endoplasmic reticulum resident protein 57 (ERp57) has a molecular weight of 57 kDa, belongs to the protein disulfide-isomerase (PDI) family, and is primarily located in the endoplasmic reticulum (ER). ERp57 functions in the quality control of nascent synthesized glycoproteins, participates in major histocompatibility complex (MHC) class I molecule assembly, regulates immune responses, maintains immunogenic cell death (ICD), regulates the unfolded protein response (UPR), functions as a 1,25-dihydroxy vitamin D₃ (1,25(OH)₂D₃) receptor, regulates the NF-κB and STAT3 pathways, and participates in DNA repair processes and cytoskeletal remodeling. Recent studies have reported ERp57 overexpression in various human cancers, and altered expression and aberrant functionality of ERp57 are associated with cancer growth and progression and changes in the chemosensitivity of cancers. ERp57 may become a potential biomarker and therapeutic target to combat cancer development and chemoresistance. Here, we summarize the available knowledge of the role of ERp57 in cancer and the underlying mechanisms.

Keywords: ERp57/PDIA3, cancer, immune response, immunogenic cell death, unfolded protein response, DNA repair.

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APA

Song, D., Liu, H., Wu, J., Gao, X., Hao, J., Fan, D. (2021). Insights into the role of ERp57 in cancer. Journal of Cancer, 12(8), 2456-2464. https://doi.org/10.7150/jca.48707.

ACS

Song, D.; Liu, H.; Wu, J.; Gao, X.; Hao, J.; Fan, D. Insights into the role of ERp57 in cancer. J. Cancer 2021, 12 (8), 2456-2464. DOI: 10.7150/jca.48707.

NLM

Song D, Liu H, Wu J, Gao X, Hao J, Fan D. Insights into the role of ERp57 in cancer. J Cancer 2021; 12(8):2456-2464. doi:10.7150/jca.48707. https://www.jcancer.org/v12p2456.htm

CSE

Song D, Liu H, Wu J, Gao X, Hao J, Fan D. 2021. Insights into the role of ERp57 in cancer. J Cancer. 12(8):2456-2464.

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