CircNT5E promotes the proliferation and migration of bladder cancer via sponging miR-502-5p

Yang, Jinhui; Liu, Xiaoyun; Dai, Guangcheng; Qu, Lanying; Tan, Bo; Zhu, Bo; Qi, Fuming; Gai, Xinyu; Cheng, Bo

doi:10.7150/jca.53385

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J Cancer 2021; 12(8):2430-2439. doi:10.7150/jca.53385 This issue Cite

Research Paper

CircNT5E promotes the proliferation and migration of bladder cancer via sponging miR-502-5p

Jinhui Yang^1*, Xiaoyun Liu^1*, Guangcheng Dai^2*, Lanying Qu¹, Bo Tan¹, Bo Zhu¹, Fuming Qi¹, Xinyu Gai¹, Bo Cheng^1✉

1. Urology and Andrology Department, Shengli OilFiled Central Hospital, Dongying, 257034, Shandong, China.
2. Department of Urology, The Second Affiliated Hospital of Soochow University, 215004, Suzhou, China.
* Jinhui Yang, Xiaoyun Liu and Guangcheng Dai contributed equally to this work.

Citation:

Yang J, Liu X, Dai G, Qu L, Tan B, Zhu B, Qi F, Gai X, Cheng B. CircNT5E promotes the proliferation and migration of bladder cancer via sponging miR-502-5p. J Cancer 2021; 12(8):2430-2439. doi:10.7150/jca.53385. https://www.jcancer.org/v12p2430.htm

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Abstract

Accumulating evidence suggest that circRNA RNAs (circRNAs) play important roles in tumor formation and development. circNT5E has been shown to be an oncogenic gene in several types of cancer, and the high expression of circNT5E lead to tumorigenesis and cancer progression. However, the precise role of circNT5E in bladder cancer (Bca) has not been characterized. In this study, we observed that circNT5E expression was augmented in Bca tissues compared with that in adjacent normal tissues, and its expression level was positively associated with larger tumor size and lower survival rate. Further experiments showed that suppression of circNT5E restrained the growth and metastasis of Bca cells in vitro. circNT5E was mainly distributed in the cytoplasm and it captured miR-502-5p to increase HOXC8 mRNA and protein expression. Moreover, decreased miR-502-5p obviously reversed the circNT5E silencing-mediated inhibition of Bca cell growth and migration. Thus, this study suggested that circNT5E may act as a pro-oncogene in the development and progression of Bca and it may become a useful tumor biomarker and promising therapeutic target for Bca treatment.

Keywords: Bladder cancer, circNT5E, NT5E, miR-502-5p, HOXC8.

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APA

Yang, J., Liu, X., Dai, G., Qu, L., Tan, B., Zhu, B., Qi, F., Gai, X., Cheng, B. (2021). CircNT5E promotes the proliferation and migration of bladder cancer via sponging miR-502-5p. Journal of Cancer, 12(8), 2430-2439. https://doi.org/10.7150/jca.53385.

ACS

Yang, J.; Liu, X.; Dai, G.; Qu, L.; Tan, B.; Zhu, B.; Qi, F.; Gai, X.; Cheng, B. CircNT5E promotes the proliferation and migration of bladder cancer via sponging miR-502-5p. J. Cancer 2021, 12 (8), 2430-2439. DOI: 10.7150/jca.53385.

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CSE

Yang J, Liu X, Dai G, Qu L, Tan B, Zhu B, Qi F, Gai X, Cheng B. 2021. CircNT5E promotes the proliferation and migration of bladder cancer via sponging miR-502-5p. J Cancer. 12(8):2430-2439.

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