Correlation of PD-L1 and SOCS3 Co-expression with the Prognosis of Hepatocellular Carcinoma Patients

Chen, Liuxi; Huang, Xingxing; Zhang, Wenzheng; Liu, Ying; Chen, Bi; Xiang, Yu; Zhang, Ruonan; Zhang, Mingming; Feng, Jiao; Liu, Shuiping; Duan, Ting; Chen, Xiaying; Wang, Wengang; Pan, Ting; Yan, Lili; Jin, Ting; Li, Guohua; Li, Yongqiang; Xie, Tian; Sui, Xinbing

doi:10.7150/jca.46158

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2020; 11(18):5440-5448. doi:10.7150/jca.46158 This issue Cite

Research Paper

Correlation of PD-L1 and SOCS3 Co-expression with the Prognosis of Hepatocellular Carcinoma Patients

Liuxi Chen^1,2*, Xingxing Huang^1,2*, Wenzheng Zhang^1,2, Ying Liu^1,2, Bi Chen^1,2,3, Yu Xiang², Ruonan Zhang^1,2,3, Mingming Zhang², Jiao Feng², Shuiping Liu², Ting Duan², Xiaying Chen², Wengang Wang^1,2, Ting Pan², Lili Yan², Ting Jin², Guohua Li², Yongqiang Li^1✉, Tian Xie^1,2,3✉, Xinbing Sui^1,2,3✉

1. Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
2. Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang, China.
3. State Key Laboratory of Quality Research in Chinese Medicines, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, P.R. China.
*These authors contributed equally to this work.

Citation:

Chen L, Huang X, Zhang W, Liu Y, Chen B, Xiang Y, Zhang R, Zhang M, Feng J, Liu S, Duan T, Chen X, Wang W, Pan T, Yan L, Jin T, Li G, Li Y, Xie T, Sui X. Correlation of PD-L1 and SOCS3 Co-expression with the Prognosis of Hepatocellular Carcinoma Patients. J Cancer 2020; 11(18):5440-5448. doi:10.7150/jca.46158. https://www.jcancer.org/v11p5440.htm

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Abstract

Purpose: To investigate the correlation between the expression of PD-L1, SOCS3 and immune-related biomarkers CD276, CD4, CD8 in hepatocellular carcinoma (HCC) and further determine the relationship with clinicopathologic characteristics and the prognostic value of their co-expression in HCC patients.

Methods: We assessed the expression of PD-L1, CD276, SOCS3, CD4 and CD8 by immunohistochemistry in tumor tissue from 74 HCC patients who underwent curative hepatectomy.

Results: High expression of PD-L1 was significantly associated with high Edmondson grade (p<0.01) and elevated enzyme (p=0.037); high expression of CD276 was significantly correlated with high Edmondson grade (p=0.021); high expression of SOCS3 was significantly associated with age (p=0.026) and tumor size (p=0.041), while PD-L1 showed no significant correlation. The expression of PD-L1, CD276, SOCS3 protein and other clinicopathological factors (sex, vascular invasion, tumor number, tumor capsule, pT stage, liver cirrhosis, HBsAg, TBiL, AFP) showed no significant correlation (p>0.05). High expression of CD8 was respectively significantly associated with worse overall survival (OS) (p=0.002). There was no significantly difference between CD4 and CD8 high-expression and overall survival (OS) (p=0.100). Both high expression of PD-L1 (p=0.003) and low expression of SOCS3 (p=0.015) was significantly associated with worse overall survival (OS). But CD276 only had a trendency (p=0.166). Additionally, multivariate Cox regression models implied that PD-L1, SOCS3, as well as both CD4 and CD8 was an independent prognostic factor for OS (p<0.05). Furthermore, HCC patients with PD-L1 low-expression and SOCS3 high-expression had a better prognostic according to the different pT stages (p<0.05).

Conclusions: We for the first time demonstrated that PD-L1 and SOCS3 were independent prognostic factor for HCC patients. Co-expression of low PD-L1 and high SOCS3 could be a better predictive marker for HCC patients.

Keywords: PD-L1, SOCS3, CD276, CD4, CD8, hepatocellular carcinoma, prognostic value

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APA

Chen, L., Huang, X., Zhang, W., Liu, Y., Chen, B., Xiang, Y., Zhang, R., Zhang, M., Feng, J., Liu, S., Duan, T., Chen, X., Wang, W., Pan, T., Yan, L., Jin, T., Li, G., Li, Y., Xie, T., Sui, X. (2020). Correlation of PD-L1 and SOCS3 Co-expression with the Prognosis of Hepatocellular Carcinoma Patients. Journal of Cancer, 11(18), 5440-5448. https://doi.org/10.7150/jca.46158.

ACS

Chen, L.; Huang, X.; Zhang, W.; Liu, Y.; Chen, B.; Xiang, Y.; Zhang, R.; Zhang, M.; Feng, J.; Liu, S.; Duan, T.; Chen, X.; Wang, W.; Pan, T.; Yan, L.; Jin, T.; Li, G.; Li, Y.; Xie, T.; Sui, X. Correlation of PD-L1 and SOCS3 Co-expression with the Prognosis of Hepatocellular Carcinoma Patients. J. Cancer 2020, 11 (18), 5440-5448. DOI: 10.7150/jca.46158.

NLM

CSE

Chen L, Huang X, Zhang W, Liu Y, Chen B, Xiang Y, Zhang R, Zhang M, Feng J, Liu S, Duan T, Chen X, Wang W, Pan T, Yan L, Jin T, Li G, Li Y, Xie T, Sui X. 2020. Correlation of PD-L1 and SOCS3 Co-expression with the Prognosis of Hepatocellular Carcinoma Patients. J Cancer. 11(18):5440-5448.

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