Combined Preoperative LMR and CA125 for Prognostic Assessment of Ovarian Cancer

Tang, Ying; Hu, Hui-quan; Tang, Fang-xiang; Lin, Dan; Shen, Rui; Deng, Li; Tang, Ya-lan; Deng, Li-hong; Zhou, Mi; Li, Jun; Su, Bin; Xu, Fan

doi:10.7150/jca.42477

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J Cancer 2020; 11(11):3165-3171. doi:10.7150/jca.42477 This issue Cite

Research Paper

Combined Preoperative LMR and CA125 for Prognostic Assessment of Ovarian Cancer

Ying Tang^1*, Hui-quan Hu^1*, Fang-xiang Tang^2*, Dan Lin², Rui Shen³, Li Deng³, Ya-lan Tang^1,2, Li-hong Deng², Mi Zhou¹, Jun Li¹, Bin Su¹, Fan Xu^{1 ✉}

1. Department of Obstetrics and Gynecology, The Affiliated Nanchong Central Hospital of North Sichuan Medical College, Nanchong, Sichuan, PR China
2. North Sichuan Medical College, Nanchong, Sichuan, PR China
3. Department of Computer Science and Technology, School of China West Normal University, Nanchong, Sichuan, PR China
*These authors contributed equally to this work.

Citation:

Tang Y, Hu Hq, Tang Fx, Lin D, Shen R, Deng L, Tang Yl, Deng Lh, Zhou M, Li J, Su B, Xu F. Combined Preoperative LMR and CA125 for Prognostic Assessment of Ovarian Cancer. J Cancer 2020; 11(11):3165-3171. doi:10.7150/jca.42477. https://www.jcancer.org/v11p3165.htm

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Abstract

Objectives: To investigate the role of inflammation-related factors, lymphocyte-to-monocyte ratio (LMR) alone and combined detection with cancer antigen 125 (CA125), in the prognostic assessment of ovarian cancer (OC).

Methods: A retrospective clinicopathologic review was performed. The receiver-operating characteristic (ROC) curves of LMR, CA125, and COLC predicting mortality in OC patients were constructed. Besides, Kaplan-Meier and Cox logistic regression models were used to plot the survival curves and determine the independent prognostic factors.

Results: A total of 214 OC patients were identified in this cohort. The mean duration of follow-up was 64 months (minimum 8 months, maximum 116 months). In this cohort, 135 cases died (63.1%), and the median progression-free survival (PFS) and overall survival (OS) were 20 and 39.5 months, respectively. Results of the multivariate Cox regression model showed that LMR≤3.8 (HR = 0.494, 95% CI: 0.329-0.742, P = 0.001) and CA125>34 U/ml (HR = 1.641, 95% CI: 1.057-2.550, P = 0.027) were significantly associated with poor PFS; and LMR≤3.8 (HR = 0.459, 95% CI: 0.306-0.688, P = <0.001) and CA125>34 U/ml (HR = 1.946, 95% CI: 1.256-3.015, P = 0.003) were significantly associated with OS. Furthermore, the area under the curve of COLC was higher (0.713) than that of LMR (0.709) or CA125 (0.583), the specificity of COLC was higher (75.9%) than that of LMR (62%) or CA125 (40.5%) in predicting mortality in OC patients.

Conclusions: LMR alone and combined with CA125 might be used as predictive markers in OC. Furthermore, as a prognostic factor, COLC might have a higher specificity to predict the outcome.

Keywords: ovarian cancer, lymphocyte-to-monocyte ratio (LMR), CA125, prognosis

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APA

Tang, Y., Hu, H.q., Tang, F.x., Lin, D., Shen, R., Deng, L., Tang, Y.l., Deng, L.h., Zhou, M., Li, J., Su, B., Xu, F. (2020). Combined Preoperative LMR and CA125 for Prognostic Assessment of Ovarian Cancer. Journal of Cancer, 11(11), 3165-3171. https://doi.org/10.7150/jca.42477.

ACS

Tang, Y.; Hu, H.q.; Tang, F.x.; Lin, D.; Shen, R.; Deng, L.; Tang, Y.l.; Deng, L.h.; Zhou, M.; Li, J.; Su, B.; Xu, F. Combined Preoperative LMR and CA125 for Prognostic Assessment of Ovarian Cancer. J. Cancer 2020, 11 (11), 3165-3171. DOI: 10.7150/jca.42477.

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CSE

Tang Y, Hu Hq, Tang Fx, Lin D, Shen R, Deng L, Tang Yl, Deng Lh, Zhou M, Li J, Su B, Xu F. 2020. Combined Preoperative LMR and CA125 for Prognostic Assessment of Ovarian Cancer. J Cancer. 11(11):3165-3171.

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