J Cancer 2019; 10(27):6829-6836. doi:10.7150/jca.35939
Triglyceride-to-high density lipoprotein cholesterol ratio predicts clinical outcomes in patients with gastric cancer
1. General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
2. Department of Clinical Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
3. Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
#These authors have contributed equally to this work.
Sun H, Huang X, Wang Z, Zhang G, Mei Y, Wang Y, Nie Z, Wang S. Triglyceride-to-high density lipoprotein cholesterol ratio predicts clinical outcomes in patients with gastric cancer. J Cancer 2019; 10(27):6829-6836. doi:10.7150/jca.35939. Available from http://www.jcancer.org/v10p6829.htm
Correlation of triglyceride (TG)-to-high density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) and the survival of gastric cancer (GC) remain unclear. The purpose of this study was to explore the precise effect of preoperative TG/HDL-C on clinical outcomes in GC patients. Patients with GC were enrolled from 2006 to 2014. A total of 957 individuals from a single center were divided into prospective training and retrospective test cohorts. The optimal cutoff value of TG/HDL-C was determined using X-tile software to separate the training cohort into low and high survival groups according to TG/HDL-C levels. Survival analyses were performed using Kaplan-Meier curves and a Cox proportional hazards regression model. Preoperative TG/HDL-C and clinical outcomes were obtained to determine the prognostic significance of serum lipids in the training and test cohorts. We observed that high TG and TG/HDL-C were significantly correlated with poor outcome in GC patients, and high TG/HDL-C harbored the highest area under curve to independently predict 5-year overall survival in two cohorts. Furthermore, c-index of the prognostic nomogram including TG/HDL-C was significantly higher than that without it. In summary, TG/HDL-C was an efficient and independent prognostic factor to predict 5-year case fatality of GC patients and to improve the efficacy of its prognostic nomogram.
Keywords: triglyceride, high density lipoprotein cholesterol, gastric cancer, clinical outcome, nomogram