J Cancer 2019; 10(20):4765-4776. doi:10.7150/jca.32650 This issue Cite

Review

Salmonella-Mediated Cancer Therapy: An Innovative Therapeutic Strategy

Ze Mi, Zhi-Chao Feng, Cheng Li, Xiao Yang, Meng-Tian Ma, Peng-Fei Rong

Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China

Citation:
Mi Z, Feng ZC, Li C, Yang X, Ma MT, Rong PF. Salmonella-Mediated Cancer Therapy: An Innovative Therapeutic Strategy. J Cancer 2019; 10(20):4765-4776. doi:10.7150/jca.32650. https://www.jcancer.org/v10p4765.htm
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Abstract

Bacterial-mediated cancer therapy (BMCT) has become a hot topic in the area of antitumor treatment. Salmonella has been recommended to specifically colonize and proliferate inside tumors and even inhibit tumor growth. Salmonella typhimurium (S. typhimurium) is one of the most promising mediators, which can be easily manipulated. S. typhimurium has been engineered and designed as cancer-targeting therapeutics, and can be improved by combining with other therapeutic methods, e.g. chemotherapy and radiotherapy, which regulate the tumor microenvironment synergistically. In view of all these strengths, the engineered attenuated strains have significant advantages for tumor diagnosis and treatment. This treatment has also been approved by the FDA for clinical trial. In this review, we summarized the recent progress and research in the field of Salmonella -mediated cancer therapy.

Keywords: bacterial-mediated cancer therapy, Salmonella, tumor microenvironment, combination therapy


Citation styles

APA
Mi, Z., Feng, Z.C., Li, C., Yang, X., Ma, M.T., Rong, P.F. (2019). Salmonella-Mediated Cancer Therapy: An Innovative Therapeutic Strategy. Journal of Cancer, 10(20), 4765-4776. https://doi.org/10.7150/jca.32650.

ACS
Mi, Z.; Feng, Z.C.; Li, C.; Yang, X.; Ma, M.T.; Rong, P.F. Salmonella-Mediated Cancer Therapy: An Innovative Therapeutic Strategy. J. Cancer 2019, 10 (20), 4765-4776. DOI: 10.7150/jca.32650.

NLM
Mi Z, Feng ZC, Li C, Yang X, Ma MT, Rong PF. Salmonella-Mediated Cancer Therapy: An Innovative Therapeutic Strategy. J Cancer 2019; 10(20):4765-4776. doi:10.7150/jca.32650. https://www.jcancer.org/v10p4765.htm

CSE
Mi Z, Feng ZC, Li C, Yang X, Ma MT, Rong PF. 2019. Salmonella-Mediated Cancer Therapy: An Innovative Therapeutic Strategy. J Cancer. 10(20):4765-4776.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
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