J Cancer 2019; 10(18):4286-4292. doi:10.7150/jca.31766

Research Paper

High Expression Levels of ACTN1 and ACTN3 Indicate Unfavorable Prognosis in Acute Myeloid Leukemia

Xinrui Yang1, Yifan Pang2, Jilei Zhang1, Jinlong Shi3, Xinpei Zhang1, Gaoqi Zhang1, Siyuan Yang1, Jing Wang1, Kai Hu1, Jijun Wang1, Hongmei Jing1, Xiaoyan Ke1✉, Lin Fu1✉

1. Department of Hematology and Lymphoma Research Center, Peking University, Third Hospital, Beijing, 100191, China.
2. Department of Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA.
3. Department of Biomedical Engineering, Chinese PLA General Hospital, Beijing, 100853, China.

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Citation:
Yang X, Pang Y, Zhang J, Shi J, Zhang X, Zhang G, Yang S, Wang J, Hu K, Wang J, Jing H, Ke X, Fu L. High Expression Levels of ACTN1 and ACTN3 Indicate Unfavorable Prognosis in Acute Myeloid Leukemia. J Cancer 2019; 10(18):4286-4292. doi:10.7150/jca.31766. Available from http://www.jcancer.org/v10p4286.htm

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Abstract

Background: Actinins are major cytoskeletal proteins that mediate sarcomere function, and they also have important non-muscle functions such as regulating cytokinesis, cell adhesion and migration. There are four isoforms of actinins in mammals (ACTN1-4). Recently, the relationship between actinins and cancer has been discovered in many types of malignancy, yet their prognostic significance in acute myeloid leukemia (AML) remains unclear.

Methods: We collected data of 155 de novo AML patients from The Cancer Genome Atlas (TCGA) database; 85 patients received chemotherapy only and 70 patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). We divided each treatment groups into sub-groups based on the median expression levels of ACTN1-4.

Results: Survival analysis showed that in the chemotherapy-only group, high ACTN1 and ACTN3 expression were associated with shorter event-free survival (EFS) and overall survival (OS) (p<0.01). Multivariate analysis suggested that high expression of ACTN1 and ACTN3 (p<0.05) were independent poor prognostic factors. In the allo-HSCT group, ACTN1-4 expression had no impact on survival.

Conclusions: Our study suggested that high expression levels of ACTN1 and ACTN3 adversely affected the survival of AML patients, but their harmful impact could be overcome by allo-HSCT.

Keywords: acute myeloid leukemia, ACTN1, ACTN3, prognosis