1. Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou 350117, Fujian Province, People's Republic of China. 2. Central laboratory, The Fifth Hospital of Xiamen, Xiamen 361101, Fujian Province, People's Republic of China. 3. Shanhe Pharmaceutical Co., Ltd., No789, Hangang West Road, Chigang Overseas Chinese Economic Development Zone, Putian 351100, Fujian Province, People's Republic of China.
✉ Corresponding author: Dr. Yao Lin, College of Life Sciences, Qishan Campus, Fujian Normal University, Fuzhou, Fujian Province, P.R. China, 350117. Email: yaolinedu.cn; yaolinfjfzcom; Tel: +86-(0)591-22860592; Fax: +86-(0)591-22860592.
Citation:
Huang C, Tang X, Li S, Wang Q, Xie B, Xu J, Lin Y. Immunopotentiator Aikejia improves the therapeutic efficacy of PD-1/PD-L1 immunosuppressive pathway in CT26.WT cancer cell. J Cancer 2019; 10(15):3472-3480. doi:10.7150/jca.29672. https://www.jcancer.org/v10p3472.htm
Tumors can escape immunosurveillance through immunocheckpoint such as the PD-1/PD-L1 pathway. Aikejia comes from Nocardia rubra cell-wall skeleton and can increase the number of inflammatory factors and immune cells. In this work, we showed that the levels of PD-L1 increase in CT26.WT xenograft after subcutaneous injection of Aikejia in mice, but Aikejia did not induce the expression of PD-L1 in vitro. When we treated the mice with Aikejia and blocked PD-1/PD-L1 pathway in vivo at the same time, the CT26.WT xenografts were significantly inhibited or eliminated, which was better than single treatment alone. Our results suggested that Aikejia may be an effective adjuvant for PD-1/PD-L1 immunotherapy.
Keywords: PD-L1, Aikejia, immunotherapy
Citation styles
APA
Huang, C., Tang, X., Li, S., Wang, Q., Xie, B., Xu, J., Lin, Y. (2019). Immunopotentiator Aikejia improves the therapeutic efficacy of PD-1/PD-L1 immunosuppressive pathway in CT26.WT cancer cell. Journal of Cancer, 10(15), 3472-3480. https://doi.org/10.7150/jca.29672.
ACS
Huang, C.; Tang, X.; Li, S.; Wang, Q.; Xie, B.; Xu, J.; Lin, Y. Immunopotentiator Aikejia improves the therapeutic efficacy of PD-1/PD-L1 immunosuppressive pathway in CT26.WT cancer cell. J. Cancer 2019, 10 (15), 3472-3480. DOI: 10.7150/jca.29672.
NLM
Huang C, Tang X, Li S, Wang Q, Xie B, Xu J, Lin Y. Immunopotentiator Aikejia improves the therapeutic efficacy of PD-1/PD-L1 immunosuppressive pathway in CT26.WT cancer cell. J Cancer 2019; 10(15):3472-3480. doi:10.7150/jca.29672. https://www.jcancer.org/v10p3472.htm
CSE
Huang C, Tang X, Li S, Wang Q, Xie B, Xu J, Lin Y. 2019. Immunopotentiator Aikejia improves the therapeutic efficacy of PD-1/PD-L1 immunosuppressive pathway in CT26.WT cancer cell. J Cancer. 10(15):3472-3480.
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