J Cancer 2019; 10(12):2661-2669. doi:10.7150/jca.32037

Research Paper

Marital Status and Survival in Patients with Penile Cancer

Weipu Mao1,*, Ziwei Zhang1,*, Xin Huang1, Jie Fan2,✉, Jiang Geng1,✉

1. Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China
2. Department of Pathology, Huashan Hospital, Fudan University, Shanghai, 200040, China
* First author

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Citation:
Mao W, Zhang Z, Huang X, Fan J, Geng J. Marital Status and Survival in Patients with Penile Cancer. J Cancer 2019; 10(12):2661-2669. doi:10.7150/jca.32037. Available from http://www.jcancer.org/v10p2661.htm

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Abstract

Purpose: We aimed to reveal the effects of marital status on survival outcomes in patients with penile cancer.

Methods: Patients with penile cancer who were diagnosed between 2004 and 2015 were identified by using the Surveillance, Epidemiology and End Results (SEER) database. Kaplan-Meier and Cox regressions were used to analyse the effects of marital status on overall survival (OS) and cancer-specific survival (CSS).

Results: Among 3,195 eligible patients with penile cancer, 1,951 (61.1%) patients were married, 365 (11.4%) were divorced or separated, 327 (10.2%) were widowed and 552 (17.3%) were single. The widowed patients had the worst OS median survival time (22 months) and CSS median survival time (23.5 months). Marital status was an independent prognostic factor for OS and CSS of penile cancer patients. The multivariate Cox regression showed that widowed patients exhibited the poorest OS (hazard ratio [HR]: 1.73; 95% confidence interval [CI]: 1.48-2.03, p < 0.001) and the poorest CSS (HR: 1.64; 95% CI: 1.144-1.279, p < 0.001) compared with married patients. Similar results were observed in our centre database and the subgroup analyses based on the SEER stage and grade.

Conclusions: In our study, we found that marital status was an independent prognostic factor for survival in patients with penile cancer. Additionally, widowed patients had the lowest OS and CSS compared with married patients.

Keywords: penile cancer, marital status, cancer survival, SEER