J Cancer 2018; 9(24):4742-4755. doi:10.7150/jca.23628
The Role of Galectins in Tumor Progression, Treatment and Prognosis of Gynecological Cancers
1. Department of obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University. Wenzhou 325027, China
2. MD, Department of Internal Medicine, the Second Affiliated Hospital of Wenzhou Medical University. Wenzhou 325027, China
Chetry M, Thapa S, Hu X, Song Y, Zhang J, Zhu H, Zhu X. The Role of Galectins in Tumor Progression, Treatment and Prognosis of Gynecological Cancers. J Cancer 2018; 9(24):4742-4755. doi:10.7150/jca.23628. Available from http://www.jcancer.org/v09p4742.htm
Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell apoptosis, and immune cells, causing tumor invasion, progression, metastasis and angiogenesis. Somehow, galectins are also found to exert a protective effect on cancer in a tissue-dependent way. These glycans binding proteins have been shown to be involved in the regulation of different tumor suppressor genes and oncogenes with their possible roles in human cancers. Objective of the current review is to summarize the role of galectin-1, -3 -7, and -9 in tumorigenesis of gynecological cancers. Galectin protein may be a potential therapeutic target in gynecological malignancies due to reported radio- and chemo- sensitivities, immunotherapeutic, anti-angiogenic and anti-proliferative activities. This review considers the evidence for the future research that how galectins may be important in the progression and treatment of gynecological cancers along with its potent use as a novel prognostic marker.
Keywords: galectins, gynecological cancers, cervical cancer, ovarian cancer, endometrial cancer