J Cancer 2018; 9(14):2502-2509. doi:10.7150/jca.25264

Research Paper

The significant prognostic value of ZEB1-AS1 up-regulation in patients with cancer.

Ying Ni1,*, Jian Fang2,*, Linqi Zhu1, Hui Jiang1, Yun Liu1, Renjie Miao1, Chen Shao3,✉, Shihe Shao1,✉

1. Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, China.
2. Department of Transfusion, The first affiliated hospital of Anhui medical university, Hefei, Anhui 230000, China.
3. Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
* These authors contributed equally to this work and should be considered co-first authors.

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Ni Y, Fang J, Zhu L, Jiang H, Liu Y, Miao R, Shao C, Shao S. The significant prognostic value of ZEB1-AS1 up-regulation in patients with cancer.. J Cancer 2018; 9(14):2502-2509. doi:10.7150/jca.25264. Available from http://www.jcancer.org/v09p2502.htm

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Zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) is a long non-coding RNA, which has found to unregulated in various kinds of cancer. This meta-analysis was conducted to demonstrate the association between ZEB1-AS1 expression levels and clinical outcome or prognosis of cancer patients.10 studies with 783 cancer patients were included in this meta-analysis by retrieving 5 databases (PubMed Central, EMBASE, Cochrane Library, Wiley Online Library and Medline).The result showed that overexpression of ZEB1-AS1 is significantly correlated with poor OS (Hazard ratio, HR=2.45, 95% confidence interval, CI: 1.89-3.16). ZEB1-AS1 expression levels were also associated with clinicopathological parameters including lymph node metastasis (Yes vs. No; OR=4.00, 95%CI: 2.23-7.17, P<0.00001), histologic differentiation (Moderate + poor vs. Well; OR=2.72, 95% CI: 1.69-4.37, p<0.0001), tumor metastasis and invasion (Yes vs. No; OR =2.52, 95%CI: 1.12-5.68, P=0.03) and TNM stage (III+IV vs. I+II; OR=2.76, 95 %CI 1.46-5.21, P=0.002). However, ZEB1-AS1 expression was not significantly associated with patients' gender (Male vs. Female; OR=1.20, 95% CI: 0.87-1.66; P=0.27).This meta-analysis indicated the potential value of ZEB1-AS1 as a biomarker for predicting a poor prognosis in patients with cancer.

Keywords: ZEB1-AS1, cancer, OS, meta-analysis, poor prognosis