J Cancer 2017; 8(17):3416-3429. doi:10.7150/jca.21058


Phycocyanin: A Potential Drug for Cancer Treatment

Liangqian Jiang1*, Yujuan Wang1#, Qifeng Yin1#, Guoxiang Liu1#, Huihui Liu1#, Yajing Huang2#, Bing Li1✉

1. Department of Genetics and Cell Biology, Basic medical college, 308 Ningxia Road, Qingdao University, Qingdao, China, 266071;
2. Basic medical college, 308 Ningxia Road, Qingdao University, Qingdao, China, 266071.
* The first author: Liangqian Jiang Email: jiang8014@163.com
# Contributed equally

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Jiang L, Wang Y, Yin Q, Liu G, Liu H, Huang Y, Li B. Phycocyanin: A Potential Drug for Cancer Treatment. J Cancer 2017; 8(17):3416-3429. doi:10.7150/jca.21058. Available from http://www.jcancer.org/v08p3416.htm

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Phycocyanin isolated from marine organisms has the characteristics of high efficiency and low toxicity, and it can be used as a functional food. It has been reported that phycocyanin has anti-oxidative function, anti-inflammatory activity, anti-cancer function, immune enhancement function, liver and kidney protection pharmacological effects. Thus, phycocyanin has an important development and utilization as a potential drug, and phycocyanin has become a new hot spot in the field of drug research. So far, there are more and more studies have shown that phycocyanin has the anti-cancer effect, which can block the proliferation of cancer cells and kill cancer cells. Phycocyanin exerts anti-cancer activity by blocking tumor cell cell cycle, inducing tumor cell apoptosis and autophagy, thereby phycocyanin can serve as a promising anti-cancer agent. This review discusses the therapeutic use of phycocyanin and focuses on the latest advances of phycocyanin as a promising anti-cancer drug.

Keywords: Phycocyanin, Apoptosis, Autophagy, Cancer, Cell cycle arrest.