J Cancer 2017; 8(10):1900-1907. doi:10.7150/jca.17689


Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

Pramod Kumar Maurya1, Alok Mishra1, Birendra Singh Yadav1, Swati Singh2, Prashant Kumar1, Amit Chaudhary1, Shweta Srivastava1, Suriya Narayan Murugesan1, Ashutosh Mani1✉

1. Department of Biotechnology, MNNIT Allahabad-211004
2. Center of Bioinformatics, University of Allahabad, Allahabad-211002

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Maurya PK, Mishra A, Yadav BS, Singh S, Kumar P, Chaudhary A, Srivastava S, Murugesan SN, Mani A. Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target. J Cancer 2017; 8(10):1900-1907. doi:10.7150/jca.17689. Available from http://www.jcancer.org/v08p1900.htm

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The Y-box binding protein (YB-1) is known to be a multifunctional transcription and translation factor during expression of several proteins. It is a vital oncoprotein that regulates cancer cell progression and proliferation. YB-1 is over-expressed in various human cancers such as breast cancer, colon cancer, lung cancer, gastric cancer, oesophageal cancer and glioblastoma. Nuclear expression of YB-1 is found to be associated with multidrug resistance and cancer cell progression. YB-1 is reported to regulate many cellular signalling pathways in different types of cancer proliferation. Knowledge about nuclear localization and nuclear level expression of YB-1 in different cancers has been correlated with prospective prognosis of cancer. This review discusses the prospects of YB-1 as a potential biomarker as well as therapeutic target in lieu of their role during cancer progression and multidrug resistance.

Keywords: Y Box Protein-1, cancer, biomarker