J Cancer 2016; 7(4):391-407. doi:10.7150/jca.13470


Calcitriol in Combination Therapy for Prostate Cancer: Pharmacokinetic and Pharmacodynamic Interactions

Mohamed Ben-Eltriki1, 2, Subrata Deb4, Emma S. Tomlinson Guns1, 3 ✉

1. The Vancouver Prostate Centre at Vancouver General Hospital, Vancouver, BC, Canada
2. Department of Experimental Medicine, University of British Columbia, Vancouver, B.C, Canada
3. Department of Urologic Sciences, University of British Columbia, Vancouver, B.C, Canada
4. Department of Biopharmaceutical Sciences, College of Pharmacy at Roosevelt University, Schaumburg, IL, USA

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Ben-Eltriki M, Deb S, Guns EST. Calcitriol in Combination Therapy for Prostate Cancer: Pharmacokinetic and Pharmacodynamic Interactions. J Cancer 2016; 7(4):391-407. doi:10.7150/jca.13470. Available from http://www.jcancer.org/v07p0391.htm

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Epidemiological studies indicate that vitamin D insufficiency could have an etiological role in prostate cancer. In addition, calcitriol, used in combination with currently available drugs, has the potential to potentiate their anticancer effects or act synergistically by inhibiting distinct mechanisms involved in prostate cancer growth. Clinical data have not yet provided sufficient evidence to demonstrate benefit of vitamin D due to the limited and underpowered studies that have been published to date. Here, we review the preclinical and clinical studies that describe the activity of calcitriol, applied either alone or in combination and assessed the mechanistic basis of pharmacodynamic and pharmacokinetic interactions with calcitriol. Important considerations for calcitriol use in combination therapy with respect to safety and clinical outcomes have been discussed. Many of these combinations have therapeutic potential for the treatment of several cancer types and it is anticipated that future clinical research will put emphasis on well‑designed clinical trials to establish efficacy.

Keywords: Calcitriol, prostate cancer, pharmacokinetics, CYP enzymes, metabolism, pharmacodynamics, vitamin D receptor