J Cancer 2015; 6(8):727-733. doi:10.7150/jca.11886

Research Paper

The Impact of Economic Recession on the Incidence and Treatment of Cancer

Kevin Y. Ennis1, Ming-Hui Chen2, Glenna C. Smith1, Anthony V. D'Amico3, Yuanye Zhang4, S. Aidan Quinn5, Shannon N. Ryemon1, Daniel Goltz1, Louis B. Harrison6, Ronald D. Ennis1 ✉

1. Mount Sinai Roosevelt Hospital
2. Department of Statistics, University of Connecticut
3. Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School
4. Novartis Institutes for BioMedical Research
5. Department of Pathology and Cell Biology, Columbia University
6. Moffitt Cancer Center and Research Institute, Tampa, Florida

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Ennis KY, Chen MH, Smith GC, D'Amico AV, Zhang Y, Quinn SA, Ryemon SN, Goltz D, Harrison LB, Ennis RD. The Impact of Economic Recession on the Incidence and Treatment of Cancer. J Cancer 2015; 6(8):727-733. doi:10.7150/jca.11886. Available from http://www.jcancer.org/v06p0727.htm

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Purpose: The impact of economic recessions on the incidence and treatment of cancer is unknown. We test the hypothesis that cancer incidence and treatment rates decrease during a recession, and that this relationship is more pronounced in cancers that present with mild, more easily ignored symptoms.

Methods and Materials: Data on incidence and treatment for all cancers, and breast and pancreatic cancers specifically, from 1973-2008, were collected using Surveillance Epidemiology and End Results (SEER). The data was adjusted for race, income, and education. Unemployment rate was used as the measure of economic recession. Data was log-transformed, and multivariate linear mixed regression was used.

Results: Adjusting for socioeconomic factors, the data revealed a significant inverse correlation between unemployment and rates of cancer incidence and treatment. Every 1% increase in unemployment was associated with a 2.2% (95% CI: 1.6-2.8%, p<0.001) reduction in cancer incidence, a 2.0% (1.2-2.8%, p=0.0157) decrease in surgery, and a 9.1% (8.2-10.0% p<0.001) decrease in radiation therapy (RT). Breast cancer incidence and treatment had a dramatic inverse relationship - 7.2% (6.3-8.1%), 6.7% (5.7-7.6%), and 19.0% (18.1-19.8%), respectively (p<0.001 for all). The decrease in incidence was only significant for in situ and localized tumors, but not in regional or distant breast cancer. Compared to breast cancer, pancreatic cancer had a weaker relationship between unemployment and incidence: 2.6% (1.8-3.3%, p=0.0005), surgery: 2.4% (2.0-2.7%, p<0.001), and RT: 1.9% (1.5-2.2% p<0.001).

Conclusions: Increasing unemployment rates are associated with a decrease in the incidence and treatment of all cancers. This effect is exaggerated in breast cancer, where symptoms can more easily be ignored and where there are widely used screening tests relative to pancreatic cancer.

Keywords: economic recessions, cancer, treatment