Mutual Regulation of FOXM1, NPM and ARF Proteins

Pandit, Bulbul; Gartel, Andrei L.

doi:10.7150/jca.11766

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J Cancer 2015; 6(6):538-541. doi:10.7150/jca.11766 This issue Cite

Short Research Communication

Mutual Regulation of FOXM1, NPM and ARF Proteins

Bulbul Pandit, Andrei L. Gartel^✉

Department of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA

Citation:

Pandit B, Gartel AL. Mutual Regulation of FOXM1, NPM and ARF Proteins. J Cancer 2015; 6(6):538-541. doi:10.7150/jca.11766. https://www.jcancer.org/v06p0538.htm

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Abstract

ARF, NPM and FOXM1 proteins interact with each other in mammalian cells. We showed previously that proteasome inhibitors suppress not only FOXM1 expression, but also the expression of ARF and NPM proteins. Using RNA interference we found that the depletion of each of these proteins by RNAi in human cancer HeLa cells leads to down-regulation of the two other partners, suggesting that these proteins stabilize each other in human cancer cells. Since the suppression of FOXM1 is one of hallmarks of proteasome inhibition, suppression of ARF and NPM by proteasome inhibitors may be explained in part as a secondary effect of downregulation of FOXM1 that modulate stability of ARF and NPM1 proteins.

Keywords: ARF, NPM, FOXM1, RNA interference

Citation styles

APA

Pandit, B., Gartel, A.L. (2015). Mutual Regulation of FOXM1, NPM and ARF Proteins. Journal of Cancer, 6(6), 538-541. https://doi.org/10.7150/jca.11766.

ACS

Pandit, B.; Gartel, A.L. Mutual Regulation of FOXM1, NPM and ARF Proteins. J. Cancer 2015, 6 (6), 538-541. DOI: 10.7150/jca.11766.

NLM

Pandit B, Gartel AL. Mutual Regulation of FOXM1, NPM and ARF Proteins. J Cancer 2015; 6(6):538-541. doi:10.7150/jca.11766. https://www.jcancer.org/v06p0538.htm

CSE

Pandit B, Gartel AL. 2015. Mutual Regulation of FOXM1, NPM and ARF Proteins. J Cancer. 6(6):538-541.

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