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J Cancer 2015; 6(3):270-275. doi:10.7150/jca.10638 This issue Cite

Research Paper

Amplification of Chromosome 8 Genes in Lung Cancer

Onur Baykara¹, Burak Bakir¹, Nur Buyru¹, Kamil Kaynak², Nejat Dalay^3✉

1. Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Turkey
2. Department of Chest Surgery, Cerrahpasa Medical Faculty, Istanbul University, Turkey
3. Department of Basic Oncology, I.U. Oncology Institute, Istanbul University, Turkey

✉ Corresponding author: Prof. Dr. Nejat Dalay, I.U.Oncology Institute, 34093 Capa, Istanbul, Turkey. e-mail : ndalaycom; Phone : 90 542 2168861; Fax : 90 212 5348078

Abstract

Chromosomal alterations are frequent events in lung carcinogenesis and usually display regions of focal amplification containing several overexpressed oncogenes. Although gains and losses of chromosomal loci have been reported copy number changes of the individual genes have not been analyzed in lung cancer. In this study 22 genes were analyzed by MLPA in tumors and matched normal tissue samples from 82 patients with non-small cell lung cancer. Gene amplifications were observed in 84% of the samples. Chromosome 8 was found to harbor the most frequent copy number alterations. The most frequently amplified genes were ZNF703, PRDM14 and MYC on chromosome 8 and the BIRC5 gene on chromosome 17. The frequency of deletions were much lower and the most frequently deleted gene was ADAM9. Amplification of the ZNF703, PRDM14 and MYC genes were highly correlated suggesting that the genes displaying high copy number changes on chromosome 8 collaborate during lung carcinogenesis.

Keywords: Oncogenes, copy number changes, lung cancer

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