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J Cancer 2012; 3:246-256. doi:10.7150/jca.3042 This volume Cite

Research Paper

Incidence of Malignancy after Living Kidney Transplantation: A Multicenter Study from Iran

Behzad Einollahi¹, Zohreh Rostami^1✉, Mohammad Hossein Nourbala¹, Mahboob Lessan-Pezeshki², Naser Simforoosh³, Eghlim Nemati¹, Vahid Pourfarziani¹, Fatemeh Beiraghdar¹, Mohsen Nafar³, Fatemeh Pour-Reza-Gholi³, Mitra Mahdavi Mazdeh², Manochehr Amini², Pedram Ahmadpour³, Khadijeh Makhdoomi⁴, Ali Ghafari⁴, Mohammad Reza Ardalan⁵, Hamid Taebi Khosroshahi⁵, Farshid Oliaei⁶, Shahrzad Shahidi⁷, Shahin Abbaszadeh¹, Mohammad Reza Fatahi¹, Fatemeh Hiedari¹, Atehieh Makhlogh⁸, Jalal Azmandian⁹, Hamid Reza Samimagham¹⁰, Heshmatollah Shahbazian¹¹, Fatemeh Nazemian¹², Massih Naghibi¹², Masoud Khosravi¹³, Ali Monfared¹³, Seyed Majid Mosavi¹⁴, Javad Ahmadi¹⁵, Mojgan Jalalzadeh¹⁶

1. Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2. Departement of Nephrology, Tehran University of Medical Sciences, Tehran, Iran.
3. Departement of kidney transplantation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4. Departement of Nephrology, Urmia University of Medical Sciences, Urmia, Iran.
5. Departement of Nephrology, Tabriz University of Medical Sciences, Tabriz, Iran.
6. Departement of Nephrology, Babol University of Medical Sciences, Babol, Iran.
7. Departement of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.
8. Departement of Nephrology, Sari University of Medical Sciences, Sari, Iran.
9. Departement of Nephrology, Kerman University of Medical Sciences, Kerman, Iran.
10. Departement of Nephrology, Bandar Abbas University of Medical Sciences, Bandar Abbas, Iran.
11. Departement of Nephrology, Ahvaz University of Medical Sciences, Ahvaz, Iran.
12. Departement of Nephrology, Mashhad University of Medical Sciences, Mashhad, Iran.
13. Departement of Nephrology, Rasht University of Medical Sciences, Rasht, Iran.
14. Departement of Nephrology, Ghom University of Medical Sciences, Ghom, Iran.
15. Departement of Nephrology, Artesh University of Medical Sciences, Tehran, Iran.
16. Departement of Nephrology, ZanjanUniversity of Medical Sciences, Zanjan, Iran.

✉ Corresponding author: Zohreh Rostami, MD. Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Molla Sadra Ave, Vanak Sq. Tehran, IR. Iran. Email:rostamiir

Abstract

Malignancy is a common complication after renal transplantation. However, limited data are available on post-transplant malignancy in living kidney transplantation. Therefore, we made a plan to evaluate the incidence and types of malignancies, association with the main risk factors and patient survival in a large population of living kidney transplantation. We conducted a large retrospective multicenter study on 12525 renal recipients, accounting for up to 59% of all kidney transplantation in Iran during 22 years follow up period. All information was collected from observation of individual notes or computerized records for transplant patients. Two hundred and sixty-six biopsy-proven malignancies were collected from 16 Transplant Centers in Iran; 26 different type of malignancy categorized in 5 groups were detected. The mean age of patients was 46.2±12.9 years, mean age at tumor diagnosis was 50.8±13.2 years and average time between transplantation and detection of malignancy was 50.0±48.4 months. Overall tumor incidence in recipients was 2%. Kaposis' sarcoma was the most common type of tumor. The overall mean survival time was 117.1 months (95% CI: 104.9-129.3). In multivariate analysis, the only independent risk factor associated with mortality was type of malignancy. This study revealed the lowest malignancy incidence in living unrelated kidney transplantation.

Keywords: malignancy, kidney transplantation, incidence.

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